Systemic Lupus Erythematosus (SLE)-01

24-year-old Xiaohuan has been studying medicine at a university for three years and has been suffering from systemic lupus erythematosus (SLE) for nearly 10 years. "I was diagnosed at 10, and the doctor said it was very difficult to cure, that I could only control it with medication," Xiaohuan said with a bitter smile. Over the past decade, she had to go for monthly check-ups and prescriptions, and she underwent hormone therapy, immunosuppressive therapy, and biological therapy, but none were effective. She endured severe hair loss, multiple rashes, recurrent high fevers, and widespread pain.

After various preliminary examinations, Xiaohuan met all clinical criteria for CAR-T therapy for SLE. An expert team meticulously designed a treatment plan based on her condition and carefully prepared for the cell collection process. On March 28th, the mononuclear cell collection began. On April 22nd, she started lymphodepleting chemotherapy. On April 28th, the cells were re-infused. Twenty million CAR-modified T cells were slowly infused into Xiaohuan's vein, directly targeting the lupus B cells, initiating a "precise attack, break them one by one" combat.

On June 4th, the 38th day post-infusion, Xiaohuan returned to the hospital for a follow-up. The examination results indicated that all critical indicators had dropped to normal ranges. "I no longer need hormone medications; it feels like life is just beginning," Xiaohuan said joyfully.