I-Systemic Lupus Erythematosus (SLE)-04
Lapho eneminyaka engu-7 ubudala, u-Yaoyao (igama-mbumbulu) waqala ukuqaphela ukuvela kweziqubu ezibomvu ebusweni bakhe, ezasabalala kancane kancane emzimbeni wakhe. Ngaphandle kwalezi zimpawu, waba nezilonda zomlomo eziphindaphindayo kanye nezinhlungu ezingapheli, okwabangela umkhaya wakubo ukuba ufune usizo lwezokwelapha. Ngemva kokuhlolwa okuphelele esibhedlela, u-Yaoyao watholakala ene-systemic lupus erythematosus (SLE), isifo sokuzivikela komzimba esaziwa ngenkambo yaso eyinkimbinkimbi nengalindelekile.
Phakathi neminyaka emithathu, u-Yaoyao welashwa kakhulu futhi elandelwa njalo esibhedlela. Naphezu kokwenyuka kwemithamo yemithi yokwelapha esondela ekufinyeleleni inani eliphezulu, isimo sakhe sabonisa ukuthuthuka okuncane. Ngesikhathi esifanayo, i-proteinuria yakhe, inkomba yokubandakanyeka kwezinso ku-SLE, yaqhubeka nokukhula, okubangela ukucindezeleka nokukhathazeka phakathi kwamalungu omndeni wakhe.
Ngokuthunyelwa komngane omethembayo, u-Yaoyao wethulwa esibhedlela i-Lu Daopei, lapho abamba khona iqhaza esivivinyweni esibalulekile somtholampilo se-CAR-T. Ngemva kwenqubo yokuhlola eqinile, wamukelwa ecaleni ngo-April 8. Ngokulandelayo, ngo-April 22, waqoqwa amaseli, kwathi ngoMeyi 12, wathola ukuthelwa amaseli alashwa nge-CAR-T. Ukukhishwa kwakhe ngempumelelo ngoMeyi 27 kwaphawula isikhathi esibalulekile ohambweni lwakhe lokwelashwa.
Phakathi nokulandela kwakhe inyanga yokuqala, ochwepheshe bezokwelapha babona intuthuko enkulu, ikakhulukazi ukuncipha kwe-proteinuria. Ekuvakasheni okwalandela, amaqhubu esikhumbeni sakhe ayesecishe ashabalala, kwase kusele umqubuko nje esihlathini sokudla. Ngokudabukisayo, i-proteinuria yakhe yayisixazulule ngokuphelele, futhi amaphuzu akhe e-SLE Disease Activity Index (SLEDAI-2K) abonisa isimo sesifo esithambile, esingaphansi kuka-2.
Enikwe amandla ukusebenza ngempumelelo kwe-CAR-T cell therapy, u-Yaoyao kancane kancane wayiyeka imithi yakhe ngaphansi kokuqondisa kodokotela ngokucophelela. Ngokumangalisayo, sekuphele izinyanga ezine engayisebenzisi imithi, okufakazela ukuxola okutholakala ngale ndlela yokwelapha emisha.
Uhambo luka-Yaoyao lugcizelela amandla okuguqula okwelashwa kwe-CAR-T ekulawuleni izimo ezinzima zokuzivikela komzimba njenge-SLE, okunikeza ithemba nemiphumela ebonakalayo lapho ukwelapha okuvamile kungase kusilela. Okuhlangenwe nakho kwakhe kusebenza njengesibani sethemba ezigulini nasemindenini ebhekana nezinselele ezifanayo, okubonisa ikusasa elithembisayo lemithi yomuntu siqu ekulawuleni izifo ezizimele.
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