I-Systemic Lupus Erythematosus (SLE)-03
Ngo-August 2016, uNksz A oneminyaka engu-20 ubudala waba namachashaza amancane abomvu kuwo wonke umzimba wakhe kanye nomkhuhlane ovamile, futhi waba nezibalo eziphansi zeplatelet, izinyanga eziyisikhombisa ngemva kokubeletha. Ngemva kokuhlolwa kaningi ezibhedlela zendawo, kwatholakala ukuthi une-systemic lupus erythematosus (SLE) esibhedlela sesifundazwe. Ngo-October ngawo lowo nyaka, waqala ukuthola ukwelashwa esibhedlela sendawo yangakubo.
“Eminyakeni eyisikhombisa edlule bekufanele ngivakashele esibhedlela nyanga zonke ukuze ngithole imiyalelo kadokotela, ngiyohlolwa igazi njalo, ngihlolwe umchamo, ngiphinde ngithole imithi nemijovo, kodwa isimo sasilokhu siphindaphindeka, okwakubuhlungu kakhulu,” kusho uNksz A. Ezama ukwelapha isifo sakhe, umyeni wakhe wamyisa ezibhedlela eziningana, kodwa izindleko eziphakeme azizange zilethe impumuzo esimweni sakhe. Ekugcineni, waba ne-lupus nephritis kanye ne-encephalopathy, kwathi ngoSepthemba 2022, wahlinzwa ubuchopho. Ezwa ukuthi ukwelashwa kwe-CAR-T kungase kwelaphe i-SLE, uNksz A wafuna usizo esibhedlela sethu, lapho ithimba lochwepheshe lahlaziya isimo sakhe ngokushesha.
Udokotela wachaza, "Lapho lesi siguli singeniswa okokuqala, sasine-edema evamile, i-proteinuria ebalulekile, namasosha omzimba aqondile. Sasithole ukwelashwa kwe-hormone yendabuko kanye ne-immunosuppressive, kanye nemijikelezo eyisikhombisa yokwelashwa kwebhayoloji, kodwa akukho okwaphumelela. Waba ne-lupus. i-encephalopathy, i-pulmonary hypertension, i-pulmonary fibrosis, kanye ne-renal biopsy yakhe kwabonisa ukuthi i-lupus esebenzayo. Uma kuqhathaniswa nama-agent amakhemikhali endabuko noma amasosha omzimba e-monoclonal, amaseli e-CAR-T angangena emigomeni yezicubu, asabalalise kabanzi ezicutshini, futhi enze umphumela we-cytotoxic, ikakhulukazi ngokumelene namaseli B noma amaseli e-plasma ezikhaleni zezicubu ezingafinyeleleki ngamasosha omzimba e-monoclonal. Ngaphandle ‘kwembewu yesifo,’ amasosha omzimba esiguli aya ngokuya encipha, amasosha omzimba abuyela esimweni esivamile, futhi izimpawu kancane kancane ziyadamba noma zinyamalale.” Ngakho-ke, isiguli sathola ukwelashwa kwe-CAR-T ngokuphumelelayo.
UNksz A uthe, "Manje amachashaza abomvu emzimbeni wami aphelile, futhi angisayidingi imithi ye-hormone noma ama-immunosuppressants. Ngangivame ukuhlolwa kwegazi nomchamo, kodwa manje ngiwadinga kuphela ngemva kwezinyanga eziyisithupha. Isimo sami jikelele kuhle, futhi zonke izinkomba zijwayelekile. Namuhla ukuvakasha kwami kwesithathu, futhi imiphumela yokuvakasha okubili kwangaphambilini yaba mihle kakhulu kubasebenzi bezokwelapha ngokunginika ithuba lesibili lokuphila.
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