I-Systemic Lupus Erythematosus (SLE)-01

U-Xiaohuan oneminyaka engu-24 ubudala ufundela ubudokotela enyuvesi iminyaka emithathu futhi ubephethwe yi-systemic lupus erythematosus (SLE) cishe iminyaka eyi-10. "Ngaxilongwa ngineminyaka engu-10, udokotela wathi bekunzima kakhulu ukwelapheka, bengingakulawula kuphela ngemithi," kusho uXiaohuan emamatheka kabuhlungu. Kule minyaka eyishumi edlule, kwadingeka ukuthi ayohlolwa nyanga zonke nemiyalelo, futhi welashwa ngama-hormone, welashwa nge-immunosuppressive, nokwelashwa kwebhayoloji, kodwa akukho okwaphumelela. Wabekezelela ukuqothuka kwezinwele ezinzima, ukuqubuka kaningi, umkhuhlane ophindaphindekayo, nobuhlungu obusakazekile.

Ngemuva kokuhlolwa kokuqala okuhlukahlukene, u-Xiaohuan wahlangabezana nazo zonke izindlela zokwelashwa zokwelashwa kwe-CAR-T kwe-SLE. Ithimba lochwepheshe laklama ngokucophelela uhlelo lokwelapha olusekelwe esimweni sakhe futhi lalungiselelwa ngokucophelela inqubo yokuqoqa amaseli. NgoMashi 28, kwaqala ukuqoqwa kwamaseli e-mononuclear. Ngo-Ephreli 22, waqala i-lymphodepleting chemotherapy. Ngo-Ephreli 28, amaseli aphinde afakwa. Amaseli e-T ashintshwe i-CAR ayizigidi ezingamashumi amabili afakwa kancane kancane emthanjeni ka-Xiaohuan, eqondise ngokuqondile amaseli e-lupus B, aqala ukuhlasela "okuqondile, ukuwaphula ngamunye ngamunye".

Ngomhla zizi-4 kuJuni, usuku lwama-38 ngemva kokumnika, u-Xiaohuan wabuyela esibhedlela ukuze alandelelwe. Imiphumela yokuhlolwa iveze ukuthi zonke izinkomba ezibucayi zehlele ebangeni elijwayelekile. "Angisayidingi imithi ye-hormone; kuzwakala sengathi impilo iyaqala," kusho u-Xiaohuan ngenjabulo.