Umdlavuza wesibeletho-03
UNksz K, owesifazane oneminyaka engu-55 ubudala onesizinda esicebile wazinza phesheya, wabhekana nomdlavuza ngokungalindelekile. Eminyakeni emithathu edlule, wabhekana nokungakhululeki kanye nokuqunjelwa ngaphansi kwesisu, okuhambisana nokuncipha kwesifiso sokudla. Lapho ehlolwa esibhedlela sakwelinye izwe, kwatholakala ukuthi unomdlavuza wesibeletho sesigaba IV. Ngenxa yesiteji esithuthukisiwe kanye nezimila eziningi ezitholwe ekuvuleni isisu, ukususwa ngokuhlinzwa kwakungenakwenzeka, okushiya ukwelashwa ngamakhemikhali kuwukuphela kwendlela.
Ngemva kokuhlinzwa, umaka wesimila i-CA125 ku-serum yakhe yenyuka isuka ku-1800 U/mL yaya ngaphezu kuka-5000 U/mL. Ukwelashwa ngamakhemikhali okuqhubekayo kwabonisa ukusebenza kahle okuncane, kwathi i-CA125 yakhuphuka futhi yaba ngaphezu kuka-8000 U/mL ezinyangeni eziyisithupha kamuva. Odokotela bazisa umndeni wakhe ukuthi isikhathi sakhe esisele sincane futhi bawululeka ukuba uzilungiselele ngokwengqondo. Naphezu kokufunda ubunzima besimo sakhe, uNksz K akazange abonise izimpawu zokuphelelwa ithemba. Ngaphambi kokulahla ithemba, wayefuna ukuzama i-immunotherapy.
Ngonyaka odlule, uNksz K wahlinzwa okokuqala ukuze athathwe amasampula. Ngemva kwezinyanga ezimbili zokunwetshwa kwe-ex vivo, ama-TIL aphinde abuyiselwa emzimbeni wakhe. Waphathwa imfiva ngosuku lokumnika, okwadamba ngakusasa, futhi wazizwa engcono kakhulu. Manje, ngemva kwezinyanga eziyisithupha zokwelashwa, amazinga akhe e-CA125 ahlala engaphansi kuka-18 U/mL. Ukuqhathaniswa kwezithombe ze-PET-CT kukhombisa ukuthi kumathumba okuqala angama-24 e-metastatic kuwo wonke umzimba wakhe, kusele eyodwa kuphela. NgoMashi walo nyaka, uNksz K wahlinzwa okwesibili ukuze athathwe amasampula.
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