I-Optic Nerve Injury-02

I-Stem Cell Therapy for Optic Nerve Injury: Isimangaliso Sokubuyisela Ukubona

Ebuchwephesheni banamuhla bezokwelapha obuthuthuka ngokushesha, izifo eziningi ezake zabhekwa njengezingenakwelashwa manje sezibona ithemba elisha. Namuhla, sabelana ngendaba ethinta inhliziyo mayelana nokwelashwa kwe-mesenchymal stem cell (MSC) yokulimala kwenzwa ye-optic, indlela yokwelapha eletha ithemba elivuselelwe lokubona ezigulini eziningi.

Indaba kaMnuz Zhang

UMnu. Zhang, oneminyaka engama-47, ungunjiniyela ozinikele. Nokho, impilo yakhe yashintsha kakhulu ezinyangeni ezine ezedlule ngenxa yengozi embi yemoto. Engozini, uMnu. Zhang ulimale kanzima emthanjeni wakhe wesokudla, okwadala ukwehla ngokushesha kombono waze wafiphala. Naphezu kokwelashwa kwendabuko ngama-steroids kanye nemithi ye-neurotrophic, umbono wakhe wabonisa ukuthuthukiswa okuncane. Lesi simo samkhathaza kakhulu yena nomndeni wakhe.

Ngemva kokuncoma komngane, uMnu. Zhang wafunda ngokwelashwa okusafufusa—i-mesenchymal stem cell therapy. Ngemva kokubonisana okuningiliziwe nodokotela abakhethekile kanye nokuqonda ngokugcwele inqubo yokwelapha, uMnu. Zhang wanquma ukuzama le ndlela entsha.

Ama-stem cells athathwe egazini lenkaba lamavolontiya anempilo, ahlolwe ngokuqinile futhi anwetshwa esikweni ukuze abe namandla okuvuselela nokulungisa. Njengoba ilawulwa ngomjovo we-intrathecal emgodleni wemizwa ye-optic, lawa maseli e-stem alethwa ngokuqondile esweni likaMnu. Zhang ukuze akhuthaze ukuvuselelwa kwenerve yamehlo eyonakele.

Inqubo yokwelapha yenziwa endaweni eyinyumba ukuze kuqinisekiswe ukuphepha nokunemba kuzo zonke izinyathelo. Ngesonto lokuqala ngemva kokuhlinzwa, uMnu. Zhang wabhekana nokuvuvukala okuncane nokungakhululeki endaweni yomjovo, ngaphandle kwanoma yiziphi ezinye izimpawu ezimbi. Nokho, ngokumangalisayo, ekupheleni kwenyanga yokuqala ngemva kokuhlinzwa, uMnu. Zhang waqala ukubona ukukhanya okufiphele futhi ekwazi ukubona ukukhanya okukhanyayo. Lolu shintsho lwamnikeza ithemba ngekusasa.

Ezinyangeni ezalandela, umbono kaMnu. Zhang kancane kancane waba ngcono. Ngenyanga yesithathu, wayesekwazi ukubona ukunyakaza kwezinto ezinkulu, futhi ukuhlolwa okunamandla okuvusa amadlingozi (VEP) kwabonisa ukululama okuphawulekayo kokusebenza kwe-optic nerve conduction. Ngenyanga yesithupha, ukubona kwakhe kweso lesokudla kuzinza cishe ku-0.15, okumenza akwazi ukuhlukanisa amafonti amakhulu namajamo alula, okulithuthukisa kakhulu izinga lakhe lempilo yansuku zonke.

Ukululama kukaMnu. Zhang akusho nje ukunqoba kwezokwelapha zesimanje kodwa futhi kuwubufakazi bemizamo ehlangene yabacwaningi bezokwelapha nezisebenzi zokuzithandela ezingenakubalwa. Amaseli we-Mesenchymal stem, ngokukhishwa kwezici ezihlukahlukene zokukhula kanye nama-cytokines, enze lula ukuvuselelwa nokuvuselelwa kokusebenza kwe-optic nerve eyonakele. Le ndlela yokwelapha ibonisa amandla amakhulu, inikeza ithemba ezigulini eziningi ezinjengoMnu. Zhang.