I-melanoma ye-ocular (ekuqaleni), ilandelwa yizimila zesibindi ze-metastatic-02

Ngo-2021, uNkz. Y kungazelelwe wabona okungavamile emehlweni akhe angakwesokudla. Ukuhlolwa okuphelele kwembula ukuthi wayene-melanoma yamehlo. Ngenhlanhla, itholwe ngaphambi kwesikhathi futhi yahlukaniswa njengesigaba 1A, ngamathuba angu-2% kuphela okuba ne-metastasis. Ngemva kokwelashwa nge-radiotherapy, wayengenawo umdlavuza okwesikhashana, nakuba izindleko zaziwubumpumputhe unomphela esweni elithintekile.

Nokho, ngeshwa, isimila sabuya ngonyaka olandelayo futhi saqala ukukhula ngokushesha. Ukuthwebula kwabonisa ukuthi isibindi sakhe kakade sasinamathumba angaphezu kweshumi anobukhulu obuhlukahlukene. Ngenxa yalokho, ochwepheshe batusa ukuthi abambe iqhaza ocwaningweni lomtholampilo lwe-TIL (i-tumor-infiltrating lymphocyte).

Ubaba kaNksz Y nomyeni baqoqa amarekhodi akhe ezokwelapha futhi bathintana nodokotela ezweni lonke ukuze bathole ukuhlolwa komtholampilo okufanelekile, ekugcineni bathole uhlelo lwethu. Le ndlela isebenzisa amasosha omzimba ukulwa nomdlavuza.

Odokotela bahlinza bakhipha ingxenye yesimila esibindini sikaNks. Y, bahlukanisa ama-T cell abulalayo kuso, futhi bawanweba aba izigidi eziyizinkulungwane eziyi-10 kuya kwezingu-150, bakha ibutho lama-clone cell. Leli butho elikhulu lamangqamuzana labe selibuyiselwa emzimbeni wakhe ukuze lilethe ukuhlasela okunembayo, okunamandla, nokuqhubekayo kumangqamuzana omdlavuza.

Ukutshalwa kwamaseli e-TIL kuthathe cishe amasonto amathathu futhi kwakudinga iseshini eyodwa yokwelashwa. NgoSepthemba 2023, uNksz Y wathola isonto lokwelashwa ngamakhemikhali, ukumnika kwe-TIL, kanye ne-IL-2. Lokhu kwelashwa okunamandla kwabangela imiphumela emibi kakhulu, okuhlanganisa ubuhlungu bamalunga, ukucindezeleka kokuphefumula, izimpawu zesisu, ukuqubuka, kanye nekhanda elibuhlungu.

Nokho, ngemva kokudamba kwale miphumela engemihle, kwenzeka isimangaliso. Ukwelashwa kwe-TIL kubonakale kuphumelela kakhulu. Kungakapheli unyaka, cishe zonke izimila zikaNkz. Y zase zinyamalele noma zashwabana, kwasala eyodwa. Ngo-2024, odokotela bakhipha cishe ingxenye yesibindi sakhe, okuhlanganisa nesimila sokugcina. Lapho evuka, watshelwa ukuthi zazingasekho izimpawu zokugula emzimbeni wakhe.