Ukuphayona I-CAR-T Therapy ku-B-cell Acute Lymphoblastic Leukemia Ibonisa Ukusebenza Okungakaze Kubonwe
Ucwaningo lwakamuva lulethe izindaba ezithembisayo ezigulini eziphethwe i-B-cell Acute Lymphoblastic Leukemia (B-ALL), okubonisa ukusebenza kahle okuphawulekayo nokuphepha kokwelashwa kwe-chimeric antigen receptor-T cell (CAR-T). Lolu cwaningo, olwenziwa ngokubambisana ne-BIOOCUS kanye neSibhedlela i-Lu Daopei, lugcizelela amandla okwelashwa kwe-CAR-T okuguqula ukwelashwa kwalolu hlobo olunolaka lwe-leukemia.
Ucwaningo luhlolisise ngokucophelela imiphumela yomtholampilo yeziguli eziphathwe ngamaseli e-CAR-T, kugxilwe ekhonweni lazo lokukhomba nokuqeda ama-B-cell anomdlavuza. Imiphumela yayingelula neze, nengxenye enkulu yeziguli ezithola ukuxolelwa okuphelele. Le mpumelelo ayigqamisi nje kuphela amandla okwelashwa kwe-CAR-T kodwa futhi ikubeka njengendlela yokwelapha ehamba phambili ye-B-ALL.
I-BIOOCUS, ngokubambisana neSibhedlela esidumile saseLu Daopei, ibihamba phambili kulolu cwaningo olusha. Ukusebenzisana phakathi kwalezi zinhlangano ezimbili kube nomthelela omkhulu ekuthuthukiseni ukwelashwa kwe-CAR-T, ukuqinisekisa ukuthi iziguli zithola ukwelashwa okuseqophelweni eliphezulu okusekelwe ucwaningo lwesayensi oluqinile. Ucwaningo luphinde luqinise ukubaluleka kobambiswano lwamasu ekuthuthukisweni kwezindlela zokwelapha ezisindisa impilo.
Umphakathi wezokwelapha wamazwe ngamazwe ukuqaphele lokhu okutholakele, uqaphela umthelela oguquguqukayo wokwelashwa kwe-CAR-T ku-oncology. Njengoba iziguli ze-B-ZONKE emhlabeni wonke zifuna izinketho zokwelashwa ezisebenzayo, lolu cwaningo lunikeza ithemba elisha, luqinisa indima yokwelashwa kwe-CAR-T esikhathini esizayo sokwelashwa komdlavuza.
Ezigulini kanye nemindeni elwa no-B-ALL, ucwaningo lunikeza ukukhanya kwethemba. Ngokuthuthuka okuqhubekayo nokusekelwa izinhlangano ezifana ne-BIOOCUS neSibhedlela i-Lu Daopei, ikusasa lokwelashwa kwe-CAR-T libukeka liqhakazile kunangaphambili.
Uma wena noma othandekayo ethinteka i-B-cell Acute Lymphoblastic Leukemia futhi nithanda ukuhlola ukwelashwa kwe-CAR-T, sikumema ukuthi usithinte ukuze uthole ulwazi olwengeziwe. Ithimba lethu elizinikele likhona ukuze likusekele kuzo zonke izinyathelo zohambo lwakho lokwelashwa.