I-Lu Daopei Hospital's Low-Dose CD19 CAR-T Therapy Ibonisa Imiphumela Ethembisayo Ezigulini Ze-B-ALL

Ocwaningweni oluqavile olwenziwa esibhedlela i-Lu Daopei, abacwaningi babike intuthuko enkulu ekwelapheni i-refractory noma i-B acute lymphoblastic leukemia (B-ALL) esebenzisa umthamo ophansi we-CD19 oqondiswe kumaseli we-CAR-T. Lolu cwaningo, olubandakanya iziguli ezingama-51, luveze ukuthi le ndlela entsha ayizuzanga nje kuphela amazinga aphezulu e-remission (CR) kodwa futhi yagcina iphrofayili yokuphepha evumayo.

Ithimba labacwaningi, eliholwa uDkt. C. Tong ovela eMnyangweni Wegazi kanye noDkt. AH Chang ovela ku-Clinical Translational Research Center e-Tongji University School of Medicine, liphenye imiphumela yokuphatha umthamo ophansi wamaseli e-CAR-T—cishe u-1. × 10^5/kg—uma kuqhathaniswa nemithamo ephakeme evamile. Le ndlela ihlose ukulinganisa ukusebenza kahle kokwelapha nokunciphisa imiphumela emibi kakhulu, ikakhulukazi i-cytokine release syndrome (CRS).

Imiphumela yocwaningo ibiphoqa. Phakathi kweziguli ze-B-ALL ezingama-42 eziphikisayo/eziphinde zabuyela emuva, i-36 yazuza i-CR noma i-CR ngokuthola isibalo esingaphelele (CRi), kuyilapho zonke iziguli eziyisishiyagalolunye ezinezifo ezincane ezisele (MRD) zafinyelela ukunganaki kwe-MRD. Ngaphezu kwalokho, iziguli eziningi zabhekana ne-CRS emaphakathi kuphela ukuya kwemaphakathi, kanti izimo ezinzima zazilawulwa ngempumelelo ngamasu okungenelela kusenesikhathi.

UDkt. Tong ugcizelele ukubaluleka kwalolu cwaningo, ethi, “Imiphumela ikhombisa ukuthi ukwelapha ngedosi elincane le-CD19 CAR-T cell, okulandelwa yi-allogeneic hematopoietic stem cell transplantation (allo-HCT), kunikeza inketho yokwelapha ephumelela kakhulu ezigulini eziye zathola ukwelashwa okuphumelelayo. Okunye okulinganiselwe Lokhu kwelashwa akunikezeli nje kuphela amazinga aphezulu okuphendula kodwa futhi kwehlisa kakhulu ingozi yemiphumela emibi kakhulu.

Impumelelo yalolu cwaningo igcizelela amandla emithi yokwelapha yeseli ye-CAR-T ehambisanayo ekwelapheni izifo eziyinkimbinkimbi ze-hematological. Isibhedlela i-Lu Daopei, esidume ngomsebenzi waso wokuphayona ku-cellular immunotherapy, siyaqhubeka nokuhola ekuhlinzekeni ngemithi yokwelapha esezingeni eliphezulu ezigulini ezinezimo ze-hematologic eziyinselele.

Njengoba ucwaningo luqhubeka, ithimba labacwaningi linethemba lokuqhubeka nokucwenga umthamo kanye nezinqubo zokuthuthukisa imiphumela yesiguli. Okutholwe kulolu cwaningo kushicilelwe kujenaliI-leukemiafuthi unikeze umbono onethemba ngeziguli ze-B-ZONKE emhlabeni jikelele.