Ukusebenza Kwesikhathi Eside Kwe-CD19 CAR T-Cell Therapy ekwelapheni I-Relapsed/Refractory Acute Lymphoblastic Leukemia
Entuthukweni enkulu emkhakheni we-hematology, ucwaningo lwakamuva luveze ukusebenza kahle kwesikhathi eside kwe-CD19 chimeric antigen receptor (CAR) T-cell therapy ezigulini ezihlushwa i-relapsed acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem. ukufakelwa kweseli (i-allo-HSCT). Ucwaningo, olulandela iziguli esikhathini eside, lunikeza ukuhlaziya okuphelele kwemiphumela, lunikeza imininingwane ebalulekile ngokuqina nokuphepha kwalokhu kwelashwa okusha.
Ucwaningo lulandelele ngokucophelela iziguli ezazithole ukwelashwa kwe-CD19 CAR T-cell ngemva kokubhekana nokubuyela emuva KWAKHO KONKE kulandela i-allo-HSCT. Imiphumela iyathembisa, ikhombisa ukuthi ingxenye enkulu yeziguli ithole ukuxolelwa okuphelele, nezimpendulo eziqhubekayo eziphawulwe phakathi neminyaka. Lolu cwaningo alugcizeleli nje kuphela amandla okwelapha e-CAR T-cell therapy kodwa futhi luphawula ingqopha-mlando ekwelapheni izifo ze-hematological, ikakhulukazi kulabo abanezinketho zokwelashwa ezilinganiselwe.
Ngaphezu kwalokho, ucwaningo lucubungula iphrofayili yokuphepha yokwelashwa, kubika imiphumela engemihle elawulekayo, ebihambisana nokutholwe ngaphambilini. Lokhu kuqinisa ukuthembela okukhulayo ekwelapheni kwe-CAR T-cell njengokwelashwa okusebenzayo futhi okusebenzayo kokubuyela emuva/okungahlangani BONKE, ikakhulukazi esimweni sangemuva kokufakelwa.
Njengoba umkhakha we-immunotherapy uqhubeka nokuvela, lolu cwaningo lusebenza njengesibani sethemba ezigulini nakubahlinzeki bezempilo ngokufanayo, luthembisa ikusasa lapho iziguli eziningi zingazuza khona ukuxolelwa isikhathi eside. Okutholwe akugcini nje ukufaka isandla endikimbeni ekhulayo yobufakazi obusekela ukwelashwa kwe-CAR T-cell kodwa futhi kuvula indlela yocwaningo olwengeziwe lokuthuthukisa nokwandisa ukusetshenziswa kwalo ezilungiselelweni zomtholampilo.
Ngale mpumelelo, umphakathi wezokwelapha usondela ekuguquleni isimo sokwelashwa kwezifo ze-hematological, unikeze ithemba elivuselelwe ezigulini ezilwa nalezi zimo eziyinselele.