Imithi Emisha Yokwelapha Yeseli ye-CAR-T Iguqula Ukwelashwa Kwezifo Ezilimazayo Zamaseli

Ekubuyekezweni kwakamuva okushicilelwe ku-Journal of the National Cancer Center, ochwepheshe beSibhedlela saseLu Daopei, abaholwa nguDkt. Peihua Lu, kanye nabahlanganyeli be-University of Texas MD Anderson Cancer Center, bakhanyisela intuthuko yakamuva e-CAR-T. ama-cell therapy ekwelapheni i-B-cell malignancies. Lokhu kubuyekezwa okuphelele kudingida izindlela ezimbalwa ezintsha, okuhlanganisa ukuvela kokwakhiwa kwamaseli e-CAR-T kanye nokuhlanganiswa kwezindlela zokwelapha ezitholwa ngamaseli, ukuthuthukisa ukusebenza kahle nokuphepha kokwelashwa kwezifo ezinjenge-non-Hodgkin's lymphoma (NHL) kanye ne-acute lymphoblastic leukemia (YONKE). ).

I-B-cell malignancies idala izinselele ezinkulu ngenxa yokuthambekela kwabo ukubuyela emuva futhi ithuthukise ukumelana nemithi evamile. Ukwethulwa kwamaseli T e-chimeric antigen receptor (CAR) kuguqule isimo sokwelapha, okunikeza ithemba elisha ezigulini ezibhekene nalawa makhaza anamandla. Ucwaningo lugqamisa ukuthi amaseli e-CAR T angakhiwa kanjani ngezizukulwane eziningi zokuklama, okuhlanganisa izici ezithuthukile njengama-bispecific receptors nezizinda ezibizayo, ukuze aqondise ngempumelelo amaseli wesimila futhi anciphise amathuba okuphinda aqubuke.

Isibhedlela i-Lu Daopei besihamba phambili ocwaningweni lwamaseli e-CAR-T kanye nokusetshenziswa komtholampilo, okubonisa impumelelo emangalisayo ekudaleni ukuxolelwa kwesikhathi eside. Ukuzibandakanya kwesibhedlela kulo msebenzi oyingqalabutho kugcizelela ukuzibophezela kwaso ekuthuthukiseni ukwelashwa komdlavuza kanye nokuhlinzeka ngokunakekelwa kwesimanje. Ukubuyekezwa kuphinde kuhlole amandla okuhlanganisa izindlela zokwelapha ze-CAR-T nezinye izindlela zokwelapha, ezifana ne-immunotherapy kanye nemithi ehlosiwe, ukunqoba izindlela zokumelana nokuthuthukisa imiphumela yesiguli.

Lolu shicilelo luwubufakazi bemizamo yokubambisana yabacwaningi bamazwe ngamazwe kanye nodokotela bezokwelapha ekuphusheni imingcele yokwelashwa komdlavuza. Okutholakele kunikeza amazwibela ekusasa le-oncology enembayo, lapho izindlela zokwelapha eziqondene nomuntu siqu nezintsha zingaguqula izimpilo zeziguli ezilwa nesifo esibulalayo samaseli e-B. Amagalelo eSibhedlela i-Lu Daopei kulo mkhakha ayisibani sethemba, aqhuba ukuthuthukiswa kwezindlela zokwelapha umdlavuza eziphephile nezisebenza ngempumelelo.