Ukusebenza Okuthuthukisiwe Kwe-Antitumor Kwamaseli e-CD19 CAR-T Asekelwe ku-4-1BB ekwelapheni i-B-ALL

Ocwaningweni olubalulekile lomtholampilo olwenziwa yiSibhedlela iLu Daopei kanye neLu Daopei Institute of Hematology, abacwaningi bathole ukuthi amaseli e-CD19 CAR-T asuselwa ku-4-1BB anikeza enye indlela ethembisayo kunamaseli e-CAR-T endabuko asekelwe ku-CD28 ukuze alaphe ababuyele emuva noma abahlubukayo. I-B cell acute lymphoblastic leukemia (r/r B-ALL). Lolu cwaningo, olubandakanya uphenyo oluqinile lwangaphambi komtholampilo kanye nokuhlola lomtholampilo, lubonise ukuthi amaseli e-4-1BB CAR-T awanikezi nje kuphela ukusebenza kahle kwe-antitumor kodwa futhi abonisa ukuphikelela isikhathi eside ezigulini uma kuqhathaniswa nozakwabo be-CD28.

Ithimba labacwaningi besibhedlela i-Lu Daopei laqhathanisa ngokucophelela ukusebenza kwalezi zinhlobo ezimbili zamaseli e-CAR-T. Bathola ukuthi, ngaphansi kwenqubo efanayo yokukhiqiza, amaseli e-4-1BB CAR-T abe nomthelela onamandla wokulwa nesimila kumithamo ephansi futhi abangela izehlakalo ezimbi ezimbi kakhulu kunamaseli e-CD28 CAR-T. Imiphumela yocwaningo ibonisa ukuthi ukwelashwa okusekelwe ku-4-1BB okusekelwe ku-CAR-T kungase kunikeze inketho yokwelashwa esebenza ngempumelelo nephephile ezigulini eziphethwe i-r/r B-ALL .

Lokhu okutholakele kugcizelela ukuzibophezela kweSibhedlela i-Lu Daopei ekuthuthukiseni i-hematology kanye ne-immunotherapy, enikeza ithemba ezigulini ezingazange ziphendule ekwelashweni okuvamile. Lolu cwaningo, olwalandela izindinganiso zokuziphatha eziqinile futhi lwathola imvume eKomidini Lezimiso Zesibhedlela sase-Lu Daopei, lugcizelela indima yesibhedlela ekuholeni ucwaningo olusha ekwelapheni kwamaseli e-CAR-T.

Ngale mpumelelo, i-Lu Daopei Institute of Hematology iyaqhubeka nokuvula imingcele emisha ocwaningweni lwezokwelapha, ihlinzeka ngezinketho zokwelapha ezisezingeni eliphezulu kanye nokwenza ngcono imiphumela yesiguli. Le ntuthuko iwubufakazi bokuzinikela nobungcweti bamaqembu ezokwelapha kanye nocwaningo eSibhedlela i-Lu Daopei.