Ucwaningo Oluyimpumelelo Lubonisa Ukuphepha kanye Ukusebenza Kokwelapha Kwe-CAR-T Ekwelapheni I-B-Cell Malignancies
Ucwaningo lwakamuva oluholwa uDkt. Zhi-tao Ying wasePeking University Cancer Hospital lubonise imiphumela ethembisayo ekwelapheni izifo ze-hematologic ze-B-cell ezibuyele emuva futhi eziphikisayo kusetshenziswa inoveli ye-chimeric antigen receptor T (CAR-T) cell therapy, IM19. Ishicilelwe kuIjenali yaseShayina Yezidakamizwa Ezintsha, ucwaningo lugqamisa amandla okwelapha abalulekile e-IM19 ezigulini esezikhathele izindlela zokwelashwa ezijwayelekile.
Ucwaningo lwalubandakanya iziguli eziyi-12, ezihlukaniswe ngokulinganayo phakathi kwalabo abaphethwe yi-B-cell non-Hodgkin lymphoma (NHL) kanye ne-acute B-cell lymphoblastic leukemia (B-ALL). Iziguli zalashwa ngemithamo eyahlukene yamaseli e-IM19 CAR-T, afakwa ngemva kohlobo lwe-conditioning oluhlanganisa i-fludarabine ne-cyclophosphamide. Iziphetho eziyinhloko zocwaningo zihlanganisa ukuhlola izinga lokuphendula eliphelele, ukuphikelela kwamaseli e-CAR-T, ukukhululwa kwe-cytokine, nokuqapha izenzakalo ezimbi.
(Umfanekiso ukhombisa ukululama kweziguli ze-NHL kanye ne-B-ALL)
Ngokumangalisayo, iziguli eziyi-11 kweziyi-12 zithole ukuxolelwa okuphelele, nokwanda okubonakalayo kwe-IM19 egazini lazo. Ukwelashwa kwabangela ukwanda kwama-cytokines afana ne-interleukin-6 ne-interleukin-10, okubonisa ukusabela okuqinile kokuzivikela komzimba. Okubalulekile, asikho nesisodwa seziguli esake saba ne-cytokine release syndrome enzima noma i-CAR-T cell-related encephalopathy, okugcizelela iphrofayili yokuphepha evumayo yokwelashwa.
Ucwaningo lwenziwe ithimba elihlangene lasePeking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, kanye neBeijing Immunochina Pharmaceuticals. UDkt. Ying, umbhali oholayo, ugxile ekuxilongeni nasekulapheni i-lymphomas eyingozi, kuyilapho uDkt. Jun Zhu, umbhali ohambisana nayo, enguchwepheshe owaziwayo kulo mkhakha. Lolu cwaningo lusekelwe izibonelelo ezimbalwa ezihlonishwayo, okuhlanganisa iNational Natural Science Foundation yaseChina kanye neBeijing Natural Science Foundation.
Lolu cwaningo olubalulekile luhlinzeka ngobufakazi obuningi bokuthi ukwelashwa kwe-IM19 CAR-T akusebenzi nje kuphela kodwa futhi kuphephile ezigulini ezinezinselele ze-B-cell malignancies. Ivula indlela yocwaningo lwesikhathi esizayo kanye nezicelo zomtholampilo ezingase zibe khona, enikeza ithemba elisha ezigulini ezinezinketho zokwelashwa ezilinganiselwe.