I-Bioocus Ithuthukisa I-Frontier Ekwelapheni I-Pediatric Acute Lymphoblastic Leukemia

Ingqopha-mlando ebalulekile emkhakheni wokwelashwa kwe-CAR-T, ephawulwe ukushicilelwa kwakamuva kocwaningo oluyisisekelo oluholwa nguDkt. Chunrong Tong esibhedlela sase-Lu Daopei. Lolu cwaningo, olunesihloko esithi "Experience and Challenges of Second-Generation CD19 CAR-T Cell Therapy in Pediatric Acute Lymphoblastic Leukemia," luhlinzeka ngokuhlaziywa okuphelele kokusebenza nokuphepha kwe-CD19 CAR-T cell therapy yesizukulwane sesibili ekwelapheni i-pediatric acute lymphoblastic leukemia. (BONKE).

Lolu cwaningo lugcizelela amandla okuqamba omkhiqizo we-Bioocus's CAR-T ekubhekaneni nezimo ze-hematological eziyinselele kakhulu ezinganeni. Ucwaningo luchaza kabanzi ngemiphumela yomtholampilo ebonwe ezigulini ezithole lokhu kwelashwa, lwembula amanani athembisayo okuxolelwa. Kodwa-ke, iphinde iveze izinselelo ezibucayi, ikakhulukazi ukuphathwa kwe-cytokine release syndrome (CRS) enzima kanye ne-neurotoxicity, okuhlala kuyizindawo ezibalulekile zokugxila ekuthuthukiseni ukuphepha kwesiguli.

I-Biocus's CAR-T therapy, evezwe kulolu cwaningo, isebenzisa umklamo wesizukulwane sesibili othuthukisa ukusebenza kwamaseli e-T ngokumelene namaseli omdlavuza aveza i-CD19 antigen. Le ndlela ibalulekile ekunqobeni izindlela zokumelana okuvame ukuhlangana nazo ezinganeni ezibuyela emuva noma eziphikisayo ZONKE izimo. Imiphumela ethulwe kule ncwadi ayigcini nje ngokugqamisa amandla okwelapha omkhiqizo we-Bioocus we-CAR-T kodwa futhi igcizelela ukubaluleka kokuqamba okusha okuqhubekayo kanye nocwaningo lwezokwelapha ukuze kuthuthukiswe lezi zindlela zokwelapha.

Ucwaningo lukaDkt. Tong lunikela ngemininingwane ebalulekile ekusetshenzisweni kwezindlela zokwelapha ze-CAR-T futhi luqondaniswe nomsebenzi we-Bioocus wokuthuthukisa ukwelashwa komdlavuza ngezisombululo ezisezingeni eliphezulu ze-biotechnological. Njengomholi wembulunga yonke ekuthuthukisweni kwe-CAR-T, u-Bioocus usazibophezele ekuqhubekiseni imingcele yalokho okungenzeka ekwelapheni umdlavuza, ngenhloso yokugcina yokuthuthukisa imiphumela yesiguli kanye nezinga lempilo.

Njengoba i-Bioocus iqhubeka nokusebenzisana nezikhungo zezokwelapha ezihamba phambili njengeSibhedlela i-Lu Daopei, sihlala sizinikele ekubhekaneni nezinselele ezihlonzwe kulolu cwaningo kanye nokucwenga imikhiqizo yethu ye-CAR-T ukuze kuthuthukiswe ukuphepha nokusebenza kwayo. Ukuzibophezela kwethu ekusebenzeni kahle nasekusunguleni izinto ezintsha kuqinisekisa ukuthi simi endaweni efanele yokuhola ikusasa lokwelapha umdlavuza.