I-Myasthenia gravis-02

Indaba yokwelashwa kwe-Myasthenia Gravis ka-Li Ming

U-Li Ming, uthisha oneminyaka engu-35 ubudala, waqala ukuba nezimpawu ze-myasthenia gravis (MG) eminyakeni emithathu edlule. Ekuqaleni, waqaphela i-ptosis (amajwabu amehlo alengele) kanye nenkinga yokukhuluma, kodwa izimpawu zaqhubekela phambili zaba buthaka obuvamile bemisipha, okwenza ngisho nemisebenzi yansuku zonke ibe inselele. Naphezu kokwelashwa okuhlukahlukene, okuhlanganisa ama-steroid nama-immunosuppressants, izimpawu zakhe zahlala zingalawuleki.

Ngesethulo somngane, u-Li Ming wafika esibhedlela i-Lu Daopei ukuze abambe iqhaza ocwaningweni lomtholampilo lwe-CAR-T. Ithimba lochwepheshe lenze ukuhlola okuningiliziwe kwezimpawu zakhe futhi lamlungiselela ukwelashwa kwe-CAR-T.

Inqubo Yokwelapha:

1. Isigaba Sokulungiselela: Ngaphambi kokwelashwa, u-Li Ming wenze ukuhlolwa kwezempilo okuphelele. Odokotela bahlukanise amaseli e-T emzimbeni wakhe futhi bawaguqula ngofuzo elabhorethri ukuze aveze ama-chimeric antigen receptors (CAR) aqondise ama-antigen athile ahlobene ne-myasthenia gravis.

2. Ukwandiswa Kweseli: Amaseli e-CAR-T ashintshiwe anwetshwa elabhorethri ukuze kuqinisekiswe inombolo eyanele yokwelashwa.

3. I-Chemotherapy Yokuxilonga Ngaphambi Kokuqala:Ngaphambi kokujova iseli ye-CAR-T, u-Li Ming wenza uhlobo lwe-chemotherapy lwesonto lonke ukuze anciphise inani lama-lymphocyte akhona emzimbeni wakhe, okwenza indawo engcono ukuze amaseli e-CAR-T asebenze ngempumelelo.

4. I-CAR-T Cell Infusion: Ngemva kokuqeda ukwelashwa ngamakhemikhali, u-Li Ming walaliswa esibhedlela ukuze athole i-CAR-T cell infusion. Le nqubo yenziwa ngaphansi kokuqashwa okuqinile ukuze kuvinjelwe imiphumela engemihle engaba khona.

Imiphumela Yokwelashwa:

1. Impendulo Yesikhathi Esifushane: Esontweni lokuqala ngemva kokumnika, u-Li Ming wabhekana nemfiva encane nokukhathala, ukusabela okuvamile kwesikhathi esifushane ekwelashweni kweseli ye-CAR-T. Emasontweni amabili kamuva, i-ptosis yakhe nobunzima bokukhuluma kwaba ngcono kakhulu, futhi amandla akhe aqala ukubuya.

2. Ukuthuthukiswa Kwesikhathi Esimaphakathi: Ezinyangeni ezimbili kamuva, izimpawu zika-Li Ming zase zidambe ngokuphawulekayo. Wakwazi ukuqalisa kabusha imisebenzi evamile yokufundisa, ukusebenza kahle kwakhe kwaba ngcono, futhi izinga lakhe lempilo labonisa ukuthuthuka okukhulu.

3. Imiphumela Yesikhathi eside: Ezinyangeni ezintathu ngemuva kokwelashwa, uLi Ming wayengasancikile emithini yangaphambilini. Ukuhlolwa kokulandelela kwabonisa ukuthi isimiso sakhe somzimba sokuzivikela ezifweni sasisesimweni esihle, kungekho miphumela emibi ebonwe.

Ngokwelashwa kwamaseli e-CAR-T, i-myasthenia gravis ka-Li Ming yalawulwa kakhulu. "Ngibonga kakhulu ngokwelashwa kwe-CAR-T kanye nethimba lezokwelapha elizinikele ngemizamo yabo," kusho uLi Ming echiphiza izinyembezi, exhawula udokotela lapho ephuma.