I-Myasthenia gravis-01

Indaba yokwelashwa kwe-Myasthenia Gravis ka-Zhang Wei

U-Zhang Wei, unjiniyela wesoftware oneminyaka engama-32, waqala ukuba nezimpawu ze-myasthenia gravis (MG) eminyakeni emibili edlule. Ekuqaleni, wayene-ptosis (amajwabu amehlo alengele) nokungaboni kahle, kodwa izimpawu zakhe zaba zimbi ngokuhamba kwesikhathi, okuholele ekubeni buthaka kwezicubu ezivamile okwathinta kakhulu umsebenzi wakhe nokuphila kwansuku zonke. Naphezu kokwelashwa okuhlukahlukene, okuhlanganisa imishanguzo ye-anticholinesterase, ama-immunosuppressants, ne-intravenous immunoglobulin, izimpawu zakhe zaqhubeka futhi ziphindaphinda njalo.

Njengoba izindlela zokwelapha zendabuko zibonakala zingasebenzi, odokotela baphakamise ukuthi u-Zhang Wei azame indlela entsha yokwelapha: Ukwelashwa kwamaseli e-CAR-T. Lokhu kwelashwa okusha kusebenzisa ubunjiniyela bezakhi zofuzo ukuze kulungiswe ama-T cell esiguli, okuwenza akwazi ukukhomba nokuqeda amangqamuzana angavamile ahlobene nesifo.

Ngemuva kokuhlolwa okuphelele, uZhang Wei ubonwe efanelekile ukwelashwa. Odokotela baqale bahlukanisa ama-T cell emzimbeni wakhe futhi bashintsha izakhi zofuzo futhi bawandisa elabhorethri. U-Zhang Wei wabe esethola ukwelashwa ngamakhemikhali ukuze anciphise inani lama-lymphocyte akhona emzimbeni wakhe, elungiselela ukwethulwa kwamaseli e-CAR-T. Ekugcineni, amaseli e-CAR-T ashintshiwe aphinde abuyiselwa emzimbeni ka-Zhang Wei.

Phakathi nesigaba sokuqala sokwelashwa, uZhang Wei wabhekana nokukhathala isikhashana, kodwa ngemva kwamasonto amabili, izimpawu zakhe zaqala ukuba ngcono kakhulu. I-ptosis kanye nokungaboni kahle kwancipha ngokuphawulekayo, futhi amandla akhe abuya kancane kancane. Ngemva kwenyanga eyodwa, ukusebenza kahle kwakhe kwaba ngcono, futhi wayesekwazi ukuqhubeka nemisebenzi evamile yansuku zonke. Ezinyangeni ezintathu ngemuva kokwelashwa, izimpawu zikaZhang Wei zase zicishe zanyamalala ngokuphelele, futhi wayengasayidingi imithi yangaphambilini. Ukuhlolwa kokulandelela kwabonisa ukuthi isimiso sakhe somzimba sokuzivikela ezifweni sasisesimweni esihle, singenayo imiphumela emibi kakhulu noma izimpawu zokuphinda kwesifo.

Ngokwelashwa kwamaseli e-CAR-T, i-myasthenia gravis ka-Zhang Wei yalawulwa kakhulu, kwathuthukisa kakhulu izinga lakhe lempilo namandla akhe okusebenza. Lokhu kwelashwa kunikeza ithemba elisha ezigulini eziningi ze-myasthenia gravis.