I-Multi-line Resistant Diffuse Large B-cell Lymphoma (DLBCL)

Igama:Akuhlinzekiwe

Ubulili:Owesilisa

Ubudala:Akuhlinzekiwe

Ubuzwe:Akuhlinzekiwe

Ukuxilongwa:I-Multi-line Resistant Diffuse Large B-cell Lymphoma (DLBCL)

Xhumana nathi

UMnu. X, isiguli sesilisa, wethulwe nge-multi-line resistant diffuse big-cell lymphoma (DLBCL), isimo esiyinselele esibonakala ngokumelana nesimila emigqeni eminingi yokwelashwa. Ekuhlolweni kokuqala, uMnu X wakhononda ngobuhlungu obukhulu besisu, okwenza uphenyo olwengeziwe.

Ucwaningo lwe-imaging, okuhlanganisa Umfanekiso we-1, lwembula inqwaba enkulu emgodini wesisu, okubonisa ukubandakanyeka okukhulu kwezifo. Ukuba khona kwenqwaba enjalo akugcinanga nje ngokuba nesandla ekuphathekeni kabi kwesisu sikaMnu. X kodwa futhi kwaphakamisa ukukhathazeka ngokuqhubeka nokuba nolaka kwe-lymphoma yakhe.

Ngokucabangela impumelelo elinganiselwe yemigqa yokwelapha yangaphambilini kanye nesidingo esiphuthumayo sokungenelela okuphumelelayo, uMnu. X wabhaliswa esivivinyweni somtholampilo se-CD19+22 CAR-T cell therapy. Ngemva kokuthatha izinyathelo zokulungiselela ezidingekayo, okuhlanganisa nokwelashwa kusengaphambili, uMnu. X uthole ukumnika amaseli e-CD19+22 CAR-T.

Ngokuphawulekayo, Umfanekiso wesi-2, othathwe ezinyangeni ezintathu ngemva kokubuyiselwa kwamaseli e-CD19+22 CAR-T, wabonisa ukunyamalala okuphelele kwesisindo sesisu. Le mpendulo ephawulekayo ekwelashweni yabonisa umphumela ophumelelayo, futhi i-lymphoma yaqedwa ngokuphumelelayo.

Kulo lonke uhambo lwakhe lokwelashwa, uMnu. X wathola ukunakekelwa okuphelele nokusekelwa eqenjini lezokwelapha. Lokhu kwakuhlanganisa ukuqapha ngokucophelela isimo sakhe, ukuphathwa kwemiphumela emibi ehlobene nokwelashwa, nokusekelwa ngokomzwelo ukuze kumsize abhekane nezinselele zokulwa nomdlavuza.

Ukwengeza, ngale kokunakekelwa kwezempilo, sinikeze uMnu. X ngezinhlobonhlobo zezinsizakalo zokuqinisekisa inhlalakahle yakhe iyonke phakathi nokwelashwa kwakhe. Lokhu kwakuhlanganisa ukumlungisela indawo yokuhlala enethezekile, ukumnika ukudla okunomsoco ofanelana nezidingo zakhe zokudla, ukuhlela izinto zokuhamba lapho ebonana khona nezidingo zohambo, nokumnikeza ukusekelwa ngokwengqondo yena nomndeni wakhe ukuze abasize badlule kulesi sikhathi esiyinselele.

Icala likaMnu. X ligqamisa amandla emithi emisha efana ne-CAR-T cell therapy ekunqobeni i-DLBCL engazweli yemigqa eminingi. Igcizelela ukubaluleka kocwaningo oluqhubekayo kanye nentuthuko emkhakheni we-oncology ukunikeza ithemba kanye nezinketho zokwelapha ezisebenzayo ezigulini ezibhekene nomdlavuza okunzima ukwelapha njenge-DLBCL.