FAQ-Ukwelashwa

Q.
Kuyini ukufakelwa kwegazi nomnkantsha (BMT)?

A.

Ukufakelwa kwegazi nomnkantsha kuwuhlobo olukhethekile lokwelapha kubantu abanezinhlobo ezithile zomdlavuza noma ezinye izinkinga zomnkantsha. Ekufakeni igazi nomnkantsha wethambo, amangqamuzana avame ukutholakala emnkantsheni ayathathwa, alungiswe futhi abuyiselwe esigulini noma komunye umuntu. Inhloso yokufakelwa igazi nomnkantsha wethambo ukunikeza umuntu amangqamuzana omnkantsha anempilo ngemva kokuba owawo umnkantsha ongaphilile ususiwe.

Ukufakelwa kwegazi nomnkantsha kusetshenziswe ngempumelelo kusukela ngo-1968 ukwelapha izifo ezifana ne-leukemia, i-lymphoma, i-aplastic anemia, ukuphazamiseka kokuzivikela komzimba kanye nomdlavuza oqinile wesimila.
Q.
Ingakanani isikhathi sokuhlala esibhedlela esilinganiselwe se-BMT?

A.
Ukufakelwa komnkantsha kulinganiselwa ukuthi ukuhlala esibhedlela cishe amasonto angama-4-6. Kodwa-ke, kuzodingeka ukuthi uhlale ngaphakathi kwedolobha okungenani izinyanga eziyisi-6 njengoba ukulandelela njalo kwe-BMT kuyadingeka.
Q.
Ubani ongazuza ngokufakwa kwegazi nomnkantsha (BMT)?

A.
Izifo ezilandelayo yizona ezivame kakhulu ukusizakala ngegazi noma ukufakelwa komnkantsha:

- I-leukemia

- I-anemia enkulu ye-aplastic

- Lymphomas

- I-myeloma eminingi

- Izifo zokuntuleka kwamasosha omzimba
Q.
Kuyini ukwelashwa kwe-CAR-T?

A.
Ukwelashwa kweseli kwe-Chimeric antigen receptor T (CAR-T) kuwukwelashwa okusha kwezinhlobonhlobo zomdlavuza. Umqondo uwukukhipha amaseli e-T esiguli futhi awenze ngofuzo ukuze aveze i-chimeric antigen receptor (CAR) ebona i-antigen ethile ehambisana nesimila (TAA). Ngenxa yalokho, lapho ama-T-cell aveza i-CAR ephinde afakwa emzimbeni wesiguli, azokhomba futhi aqede amaseli e-TAA aveza isimila.
Q.
Yiziphi iziguli ezizuzayo ku-CAR-T?

A.
Ukuhlolwa komtholampilo kwe-CAR-T okweziguli ezine-B-cell acute lymphoblastic leukemia (B-ALL), i-B-cell lymphoma kanye ne-myeloma eminingi ezibuyele emuva noma ezingasafuni ukwelashwa ngamakhemikhali.
Q.
Kufanele sihlale isikhathi esingakanani esibhedlela e-CAR-T?

A.

Uhlolo lomtholampilo lwe-CAR-T luthatha cishe amaviki angu-6-8, lokho kuncike esimweni sesiguli ngasinye.
Q.
Ithini inqubo yokwelapha ye-CAR-T?

A.
Q.
Mangaki ama-CAR-T osuwenzile?

A.
Kusukela ngo-2015, sesiqede cishe izivivinyo zomtholampilo ze-CAR-T ezingaba ngu-300 ze-B-ALL, B-cell lymphoma kanye ne-myeloma eminingi ngemiphumela emihle kakhulu. Safingqa amacala okuqala angama-51 futhi sawashicilela ku-Journal of Leukemia ngo-2017.
Q.
Lithini izinga lakho lempumelelo ye-CAR-T?

A.
Isilinganiso esiphelele sokuxolelwa besingaphezu kwama-90%.
Q.
Iyini inzuzo yokuba nokufakelwa komnkantsha (BMT) ngemva kwe-CAR-T?

A.
Nakuba izinga lokuxolelwa okuphelele (CR) lokwelashwa kwe-CAR-T liphezulu, kusenengozi yokuphinda ugule. Ucwaningo luye lwabonisa ukuthi ukuhlanganisa i-BMT ngemva kwe-CAR-T ye-B-ALL kungase kunyuse izinga lokwelapha elingaba khona.
Q.
Ngiyithola kanjani i-aphoyintimenti?

A.
Ungathola i-aphoyintimenti ngabamele umnyango wethu wamazwe ngamazwe.
Q.
Yimaphi amadokhumenti okufanele ngihambe nawo?

A.
Kubaluleke kakhulu ukuthi ngenkathi usohambweni ube nawo wonke amadokhumenti afanelekile atholakala kuwe kuhlanganise namakhophi ayo yonke imibiko yezokwelapha, imibiko yezifo ezihlanganisa amaslayidi ezingilazi namabhulokhi kapharafini azodingeka ukuze kubuyekezwe, imiphumela yokuthwebula ye-CT, MRI, PET- I-CT scan, isimiso segazi, i-immune histochemistry, ukuhlolwa kofuzo, imiphumela ye-chromosome uma ikhona.
Q.
Ubani ozosingatha ama-aphoyintimenti neshejuli yami ngisesibhedlela?

A.
Ithimba lethu lamazwe ngamazwe lizobhukha ama-aphoyintimenti futhi likuhlelele ukulandelelwa ngesikhathi usesibhedlela.
Q.
Iyiphi inqubo yokuthi iziguli zifune iseluleko sezokwelapha?

A.
Abasebenzi bethu beSikhungo Samazwe Ngamazwe bahlose ukuhlinzeka ngokufinyelela okulula nokunakekelwa komuntu siqu ezigulini zethu zamazwe ngamazwe. Abasebenzi bethu bazotholakala ukuze basize zonke iziguli kuzo zonke izigaba zokunakekelwa kwazo.
Q.
Ngingathola umbiko wecala lami ngemva kokwelashwa?

A.
Yebo, ngemva kokwelashwa, sizohumusha umbiko wecala lakho futhi sikunikeze umbiko wecala ngesiNgisi nesiShayina ukuze ukwazi ukukubuyisela ezweni lakini.
Q.
Ingabe ukhona ozongisiza ukuthi ngiye esikhumulweni sezindiza lapho ngibuyela ekhaya ngemva kokwelashwa?

A.
Yebo, abasebenzi bethu be-International Centre bazobhukha imoto futhi bakusize ufake imithwalo yakho emotweni futhi bakuyise esikhumulweni sezindiza.