Isigaba somdlavuza we-Endometrial IVB-04

Isiguli kwakungowesifazane oneminyaka engu-55 ubudala, kanti i-histopathology ye-biopsy yaqinisekisa ukutholakala kwesigaba somdlavuza we-endometrial esingahlukanisiwe kahle IVB.

Ukuhlukaniswa okuphansi kanye nobubi obuphezulu. Isimila sakhe sase simetastasized futhi asikwazanga ukususwa ngokuphelele ngokuhlinzwa. Ukuhlola okwengeziwe kubonise ukuthi iziguli zehlise isilinganiso se-lymphocyte nokubala kanye nomsebenzi ophansi kakhulu we-NK cell. Engakwazi ukubekezelela imiphumela emibi, wayeka ukwelashwa ngamakhemikhali futhi wabamba iqhaza esivivinyweni somtholampilo samaseli entambo yegazi e-NK.

Lesi siguli sathola ukwelashwa kokuqala ngoFebhuwari 2021 futhi okwesibili ezinyangeni eziyisi-6 kamuva. Ezinsukwini ezi-4 ezilandelanayo, ukujova okukodwa kwe-intravenous kanye ne-immunophenotyping kwenziwa ngaphambi nangemva komjikelezo ngamunye wokwelashwa.

Ngemva kwenkambo yokuqala ye-immunotherapy egazini lezintambo ze-NK cells, isiguli sathola ukukhululwa okuyingxenye. Amandla akhe angokomzimba, isifiso sokudla, nezinga lokulala lase lithuthukile.

Ngemva kwenkambo yesibili yokwelashwa, umphenyi wenza i-PET-CT scan. Ukuskena kubonise ukuncishiswa kobukhulu besisindo somzimba we-uterine hypermetabolic kanye nokunciphisa okukhulu kwe-uterine metabolism kanye nevolumu uma kuqhathaniswa nangaphambi kokwelashwa. Nakuba isisindo sekhanda lesifazane esifanele kanye ne-metastasis efanele ye-10th kanye ne-11th rib yayingashintshile, ukuguqulwa kwe-metastase yamathambo kwakujwayelekile. Ama-lymph node amaningi entanyeni, i-mediastinum, i-retroperitoneum, ne-pelvis nawo anyamalala.

Ngemva kwezifundo ezimbili, isikolo sesimo somzimba sehle sisuka koku-3 saya ku-1 futhi izinga lempilo laba ngcono kakhulu.