Sabalalisa I-B-cell Lymphoma Enkulu (DLBCL)

Isiguli, owesifazane oqinile osondela eminyakeni engu-80 ubudala, wabhekana ngesibindi nokuxilonga i-Diffuse Large B-cell Lymphoma (DLBCL), ebonisa isibindi esimangalisayo empini yakhe yokulwa nalolu hlobo lomdlavuza olunolaka.

Naphezu kokukhula kwakhe, waqhubeka ezimisele ukunqoba izinselele ezazibangelwa isimo sakhe. Kodwa-ke, phakathi nezinyanga eziyisithupha ngemva kokuthola ukuthethelelwa ngokwelashwa komugqa wokuqala, waphindela emuva, okugcizelela isimo esinolaka sesifo sakhe. Naphezu kwemizamo eminingi yokwelashwa komugqa wesibili nowesithathu, umdlavuza wakhe wabonisa ukumelana nenkani, okwabeka inselele enkulu ethimbeni lakhe lezokwelapha.

Liqaphela ukuphuthuma kwesimo sakhe, ithimba lezokwelapha laqala umzamo wokuhlola ezinye izindlela zokwelapha. Isiguli sabhaliswa esivivinyweni somtholampilo esiphenya nge-CD19+22 CAR-T cell therapy, indlela esezingeni eliphezulu esebenzisa amaseli T akhiwe ngofuzo ukukhomba amangqamuzana omdlavuza aveza ama-antigen athile.

Imiphumela yayingeyinhle neze. Ngemva nje kwenyanga eyodwa kufakwe amaseli e-CD19+22 CAR-T, isiguli sathola ukukhululwa okuphelele. Lo mphumela omangalisayo awugcinanga nje ngokumisa ukuqhubeka kwesifo sakhe kodwa futhi waholela ekuqedweni ngempumelelo kwamangqamuzana omdlavuza, okuphawula umzuzu obalulekile ohambweni lwakhe lokwelapha.

Kuyo yonke le nqubo enzima, ithimba lezokwelapha lanikeza isiguli ukusekela nokunakekela okungantengantengi. Kusukela ekuqapheni eduze impendulo yakhe ekwelashweni kuya ekulawuleni noma yiziphi izehlakalo ezimbi, baqinisekisa ukuthi inhlalakahle yakhe ihlala iza kuqala.

Sicabanga ngokuhlangenwe nakho kwaso, isiguli sabonisa ukubonga okukhulu ngokunakekelwa kozwela esakuthola. “Ukuzinikela nobungcweti bethimba lami lezokwelapha bekumangalisa ngempela,” kuphawula yena. "Indlela yabo yomuntu siqu yokwelashwa inginikeze ithemba lapho ngikudinga kakhulu."

Umphumela oyimpumelelo we-CD19+22 CAR-T cell therapy ekuzuzeni ukuxolelwa okuphelele uqokomisa amandla ako njengendlela yokwelapha ethembisayo yeziguli ze-DLBCL eziphikayo. Leli cala lisebenza njengobufakazi bamandla ezindlela zokwelapha ezintsha kanye nemithi yomuntu siqu ekulawuleni umdlavuza oyinkimbinkimbi, ikakhulukazi ezigulini esezikhulile njengalona wesifazane onesibindi.

Ngaphambi & inyanga engu-1 ngemva kokumnika