Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II
Siyakuhalalisela!Isiguli esivela eNorway, u-Bjørn Simensen, esineminyaka emibili yokuxolelwa okuqhubekayo.
Umnumzane oneminyaka engu-67 ubudala u-Bjørn Simensen wethule esibhedlela ngoSepthemba 2017 ngezikhalazo zokukhwehlela nobuhlungu besifuba. Ngesikhathi sokusebenza kwakhe, watholakala ene-myeloma eminingi (IgG lambda) ISS-II. Isiguli sathola imijikelezo ye-4 ye-bortezomib, i-lenalidomide ne-dexamethasone chemotherapy. Ngemuva kwemijikelezo emi-4 iphrotheni yakhe engu-M yayingaphansi kuka-1g/l. Isiguli sabe sesiphuma isondlo se-lenalidomide (amaviki angu-10mg qdx3 ngenyanga m) esaqhubeka nayo iminyaka emi-2 elandelayo. Wahlala engenaso isifo kwaze kwaba sehlobo lika-2021 lapho ngesikhathi sokuhlolwa kokuxolelwa kwatholakala ukuthi ukhuphule i-M protein (5g/l). U-Lenalidomide wamiswa futhi waqalwa nge-carfilzomib ne-daratumumab chemotherapy kusukela ngo-Okthoba kuya ku-December 2021. Nokho, ukwelapha ngamakhemikhali akuzange kusebenze futhi i-BM MRD yangemva kwe-chemo yayinhle.
UMnu Bjørn Simensen wabonwa okokuqala esibhedlela i-Lu Daopei ngo-14 February 2022. I-BM MRD yakhe yabonisa amaseli e-plasma angamaphesenti angu-0.25 angajwayelekile. I-IEF ibonise i-IgG ne-M protein ingu-3 g/l. I-PET-CT Scan ibonise ukwanda kokuthatha kumasende ikakhulukazi alungile nawo anwetshwa lapho kuhlolwa. Kwenziwa i-testicular biopsy eyabonisa amaseli e-plasma ayingozi. Isiguli sikhethelwe ukwelashwa kwamaseli e-CART. I-preconditioning yenziwa nge-fludarabine ne-cyclophosphamide izinsuku ezi-3. Amaseli e-CAR-T afakwe ngosuku 0 (4/3/2222). Umthamo onikeziwe wawungu-0.5X10^6/kg. Ngemva kokumnika, isiguli saba ne-neutropenia fever eyayilawulwa ngama-iv antibiotics. Ukuvuvukala kwesende kwesokudla kuya ngokuya kuncipha kube usayizi ojwayelekile. Ngosuku lwe-28 ukuhlolwa kwe-BM kwakungalungile kumaseli e-plasma. Isiguli sakhishwa e-Lu Daopei ngokulandelelwa njalo esikhungweni se-hematology edolobheni lakubo.
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