Isigaba esithuthukisiwe somdlavuza we-colorectal-01

Isiguli singowesilisa oneminyaka engu-45 ubudala owatholakala enomdlavuza we-colorectal wesigaba se-IV ngoJanuwari 2023. Ekuqaleni, odokotela batusa inkambo ephelele ye-chemoradiotherapy. Kodwa-ke, ngenxa yokusabela okunamandla kwe-neurotoxicity, okuhlanganisa i-paresthesia nokuba buthakathaka kwezitho ngemva kokwelashwa ngamakhemikhali, isiguli sanquma ukukuyeka ukuqhubeka nokwelashwa ngamakhemikhali.

Ngenhlanhla, isiguli sahlangabezana nemibandela yokuqashwa kokuhlolwa komtholampilo kwe-autologous tumor-infiltrating lymphocyte (TIL) therapy futhi sakhetha ngokuzimisela ukubamba iqhaza ocwaningweni. Ekuqaleni kuka-Ephreli 2023, isiguli sathola ukujova iseli ye-TIL futhi kamuva senziwa i-PD-1 monoclonal antibody immunotherapy ngokomthetho olandelwayo wokuhlolwa ezinyangeni ezimbili ezizayo.

Ngemuva kokwelashwa, isiguli sabika ukuthuthuka okuphawulekayo kwezimpawu zesisu kanye nokululama okuhle kokusebenza kwamathumbu. I-CT scan yokuqala egcwele umzimba ngemva kokumnika ibonise ukuncipha komthwalo wesimila, ikakhulukazi esibindini nasezilonda ze-peritoneal. Njengoba ukwelashwa kwakuqhubeka, ukuqina komzimba wesiguli kanye nezinga lempilo lathuthuka kancane kancane.

Ngenyanga yesithathu yokwelashwa, ukuhlolwa kokulandelela kwabonisa ukuqhubeka kokuncipha kwesimila. Ukuhlolwa komzimba wonke kwe-PET-CT kwembula umsebenzi we-metabolic onciphe kakhulu ezilonda ze-metastatic, ezinye izilonda zinyamalala ngokuphelele. Kuze kube manje, ukulandelwa kwanyanga zonke kukhombisa ukuthi isimila sihlala sizinzile singenazo izilonda ezintsha noma izimpawu zokuphinda.