I-Acute Lymphoblastic Leukemia(T-ALL)-10
Umfana oneminyaka engu-13 ubudala ogama lakhe lingu-Yangyang wase-Panzhihua, eSifundazweni saseSichuan, wenziwa i-CAR-T elandelwa ukufakelwa ibhuloho.
U-Yangyang wethule ekuqaleni "imihuzuko ehlakazekile emzimbeni wonke ehambisana nokukhathala" ngo-Ephreli 12, 2021. Kwatholakala ukuthi une-acute lymphoblastic leukemia (T-cell subtype) enokopha okungaphakathi kwe-cranial kanye nesifo samaphaphu okuqinisekiswe ukuhlolwa komnkantsha we-MICM esibhedlela esikhulu Chongqing. Uthole imijikelezo emi-3 yokwelashwa ngamakhemikhali kwesinye isibhedlela, kodwa umnkantsha akazange aphendule. Ekuqaleni kukaJuni, waba buthakathaka emilenzeni yomibili engezansi futhi wayengakwazi ukuhamba.
Ngomhla zi-1 kuJulayi 2021, u-Yangyang wangeniswa eMnyangweni wethu We-Hematology Wadi 2. Wabhalisa esivivinyweni somtholampilo se-CD7 CAR-T ngoJulayi 8 futhi wathola i-autologous CD7 CAR-T cell infusion ngoJulayi 26 ukuze uthole ukwelashwa kwamasosha omzimba. Ezinsukwini eziyishumi nesithupha ngemva kokumnika, i-morphology yomnkantsha yabonisa ukuxola, futhi i-cytometry yokugeleza yabonisa u-0.07% we-T lymphoblasts eyingozi esolisayo. Ngemva kokwelashwa ngokomzimba, waphinde wakwazi ukuhamba ngokuzimela. Ngosuku lwama-31 ngemuva kokujova, umnkantsha wakhe wathola ukuxolelwa okuphelele.
Njengamanje, i-Yangyang idluliselwe ku-Ward 6 yoMnyango Wokufakelwa Komnkantsha Wamathambo ukuze uthole ukwelashwa okwengeziwe. UDkt. Hai waseWadi 6 uthe u-Yangyang ubelokhu ebambisana futhi enethemba kukho konke ukwelashwa kwakhe. Wenziwa i-allogeneic hematopoietic stem cell transplantation (evela kuyise) ngo-September 28. Izimo ezadalwa ozakwabo boMnyango We-Hematology zokufakelwa kwakhe ibhuloho zaziswa kakhulu.
Lezi ziguli, ngaphambi kokubhaliswa ocwaningweni lomtholampilo lwe-CD7 CAR-T, zethulwe ngezimpawu ezahlukahlukene njengokuphinda ukufakelwa kabusha, i-T/myeloid dual expression, i-refractory/resistant acute T-cell leukemia, i-central nervous system leukemia, ukopha ngaphakathi kwe-cranial, kanye ukutheleleka kwamaphaphu. Ngemva kokuhlolwa nokwelashwa ngokwelashwa kwe-CD7 CAR-T, konke kwazuza ukukhululwa okuphelele, kwahlangabezana nemiphumela elindelekile.
Isibhedlela i-Ludaopei sihlole ngenkuthalo emkhakheni wokwelashwa kwe-CAR-T futhi saqongelela ulwazi olucebile lokuphatha i-CRS. Kwabaningi ababambiqhaza, umphumela omubi kakhulu kwaba umkhuhlane ophezulu. "Ngingakwazi ukufeza ukuxolelwa okuphelele, ngakho umkhuhlane awulutho! Ngifuna abantu abaningi bazi ukuthi uLudaopei angenza i-CAR-T!" kusho uYangyang waseFujian lapho ephuma.
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