I-Acute Lymphoblastic Leukemia(T-ALL)-07
Intombazane yaseMiao ithola ukuthethelelwa okuphelele ngemva kokwelashwa kwe-CAR-T ngemva kokuphindela emuva ngemva kokufakelwa.
U-Amei, umfundi oneziqu zaseHunan wohlanga lwaseMiao, wayeshicilele amaphepha amabili e-SCI. Ngomhla zi-2 kuMbasa, 2020, wangeniswa esibhedlela sesifundazwe ngenxa yomkhuhlane obuyayo. Ukuhlolwa komnkantsha kwathola ukuthi une-acute lymphoblastic leukemia (T-ALL). Ngemva kwezifundo eziningi zokwelashwa ngamakhemikhali esibhedlela esingaphandle, umnkantsha wakhe wasala ukhululekile. Ngomhla zi-2 kuNovemba 2020, ufakwe i-allogeneic hematopoietic stem cell esibhedlela sethu (umfowethu nodadewethu, okufanayo kwe-HLA 7/10). Ngemva kokufakelwa, amangqamuzana afakwa ngempumelelo, futhi ukuhlolwa komnkantsha wamathambo okwalandela kwabonisa ukuthethelelwa okuqhubekayo.
Ngomhla ziyi-16 kuJuni, 2021 (izinyanga ezingu-7 ngemva kokufakelwa), ukuhlolwa okujwayelekile kwembula ukuphindeka ngokuphelele kwe-leukemia yakhe. Ukwelashwa ngamakhemikhali okwalandela kwahluleka ukulawula lesi sifo, futhi waba nenyumoniya negciwane le-herpes, elinezilonda ezibuhlungu emlonyeni okwenza ukugwinya kube nzima. Wangeniswa ewodini lesibili lomnyango we-hematology futhi wabhalisa esivivinyweni somtholampilo se-CD7 CAR-T.
Ithimba lezokwelapha likamqondisi u-Yang Junfang linikeze ukwelashwa okusebenzayo kokulwa nokutheleleka, ukudambisa izinhlungu, kanye nokumpontshelwa igazi eliningi kanye ne-platelet. Ngenxa yomthwalo omkhulu wesimila (ukuqhuma okungama-80% kumnkantsha kanye nokuqhuma okungama-97% egazini le-peripheral), akukwazanga ukuqoqa amaseli akhe. Ama-lymphocyte egazi angaphandle avela kumnikeli (umfowabo) aqoqwa futhi athunyelwa enkampanini ye-biotech yesiko lamaseli e-CAR-T.
Ngomhlaka-10 Agasti 2021, amaseli e-CD7 CAR-T asuselwa kumnikeli aphinde afakwa. Ngemuva kokufakwa kabusha, amaseli e-CAR-T anda afinyelela ku-54.64% egazini le-peripheral, enomkhuhlane kuphela futhi ingekho i-cytokine release syndrome ephawulekayo (CRS) noma isifo se-graft-versus-host (GVHD). Ukuhlolwa komnkantsha wethambo ngosuku lwe-16 ngemva kokufakwa kabusha kwabonisa ukuxolelwa okuphelele, namaseli e-CAR-T angu-54.13% emnkantsheni. Ngosuku lwama-36, umnkantsha waqhubeka nokubonisa ukukhululeka okuqhubekayo. Njengamanje, isimo sakhe sengqondo, ukulala, nesifiso sokudla kuhle, futhi uyalulama.
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