Unyango lwe-TIL lutyhilwe: Ukuphonononga i-Landscape ye-Cancer Immunotherapy
Yintoni iTils Therapy?
Unyango lwe-TILs lubandakanya ukukhupha i-tumor-infiltrating lymphocytes (TILs), ezona ziiseli ezichanekileyo zendalo ezichasene ne-tumor emzimbeni wesigulana, ukusuka kwithumba kwaye uzilime ngamanani amakhulu kwilebhu. Ezi TILs zisebenze ziphinda zifakwe emzimbeni wesigulana ukuze zomeleze amandla amajoni omzimba ekujoliseni nasekubulaleni iiseli zomhlaza. Ii-TILs zisebenza ngokuqaphela iimpawu ezithile kwiiseli zomhlaza kwaye ziqalise impendulo yokuzikhusela kuyo, ekugqibeleni ikhokelele ekutshatyalalisweni kwethumba.
Yintoni inkqubo yoNyango lweTils?
Iziphumo zeklinikhi zeTils Therapy
Ngokusekelwe kwiziphumo zonyango lwethu lwezonyango, ukusebenza ngokupheleleyo kwe-TILs monotherapy ifikelela phezulu ukuya kuma-40%, iyenza ibe yeyona ndlela isebenzayo yonyango lwethumba ngaphandle kotyando olukhoyo ngoku.I-Bioocus ithunga isicwangciso sonyango esibanzi kwisigulane ngasinye. Enye okanye unyango oluninzi luya kudibaniswa nonyango lwe-Tils, oluya kwandisa izinga elisebenzayo lilonke ukuya ngaphezu kwe-80%. Unyango oludibeneyo lujolise ekunciphiseni umthwalo wethumba kwixesha elifutshane, kwaye i-tils inika ithuba lokuba isigulane sifumane unyango ekuhambeni kwexesha.
Izinto eziluncedo kwiTils Therapy
Ukucaciswa okuphezulu:iiseli T ithumba ezithile sensitized yi antigens ithumba, ziqatshelwe TCRs ezininzi
I-tropism eyomeleleyo:ukubonakaliswa okuphezulu kwe-chemokine receptors, i-tumor tropism enamandla, kunye nesenzo esikhawulezayo
Ukubulala amathumba:Ii-TILs ziyasebenza kwaye zandiswa ukuya kwi-109-1011, kwaye iiseli zomhlaza ezishiyekileyo ziyacinywa emva kotyando.
Isiphumo esiqhubekayo:Ubungakanani beeseli ze-T zememori ziphezulu, kwaye zinokuphila emzimbeni ixesha elide kwaye zihlale zibekwe esweni.
Ukhuseleko oluphezulu:ukukhutshwa, ukukhulisa, akukho mpendulo yokwaliwa, kunye ne-SAE yeeseli ze-TILs ezivela kwizigulane ngokwazo
Iimpawu zoNyango lweTils
Unyango lwe-Tils lubonakalise ukusebenza ngempumeleloI-NSCLC(umhlaza wemiphunga weseli ongeyiyo encinci),IMelanoma, uMhlaza wamabele,Umhlaza woMlomo weSibeleko,kunye noMhlaza we-Ovarian.
Zeziphi izihlunu ezinokusetyenziswa ukukhupha ii-TIL?
Ngaphandle kokutsalwa kotyando lwe-tumor ephambili, izicubu ze-tumor ezingaphezulu, i-lymph nodes, i-pleural effusion, i-ascites, njl., inokuzanywa ukutsalwa. Uluhlu olusebenzayo lulandelayo: isilonda sokuqala ≥ i-metastatic lesion ≥ lymph nodes ≥ ascites.
Ngaba zonke izigulana zingahlakulela ngempumelelo ii-TIL?
Inkqubo yethu yokulima i-TILs ephuhliswe ngokuzimeleyo ifezekisa izinga lempumelelo ye-≥85%. Ngesampulu yethishu eqhelekileyo ≥1cm3, iibhiliyoni zee-TIL zinokulinywa, kwaye iiseli zibonisa umsebenzi owomeleleyo we-cytotoxic."
Iziphumo ebezingalindelekanga zonyango lwe-TILs?
I-1.TILs ziiseli zesigulane, ngoko akukho mngcipheko wokugatywa, ukuqinisekisa ukhuseleko oluphezulu.
2. Ukusabela okungathandekiyo: Umkhuhlane uxhaphakile (ngenxa yokukhululwa kwee-cytokines ngexesha le-TILs ye-cell-mediated tumor clearance, ebangela umkhuhlane wexeshana, ngokuqhelekileyo awufuni unyango oluthile kwaye uzisombulule ngokwawo).
I-3.Ezinye iziphumo ezimbi ezichazwe kwizifundo ziquka i-thrombocytopenia, i-febrile neutropenia, i-hypertension, njl., ubukhulu becala kubangelwa ii-TILs ngokudibanisa nezinye iziyobisi ezifana ne-chemotherapy yangaphambili (i-cyclophosphamide + fluorouracil), i-high-dose IL-2, i-PD-1 ii-antibodies ze-monoclonal, njl.
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