Inkqubo yeLupus Erythematosus (SLE)-04
Xa wayeneminyaka esi-7 ubudala, uYaoyao (igama elinguzenzele) waqalisa ukuphawula ukuvela kwerhashalala ebomvu ebusweni bakhe, eyathi ngokuthe ngcembe yasasazeka kuwo wonke umzimba wakhe. Ngaphandle kwezi mpawu, waba nezilonda emlonyeni neentlungu ezingapheliyo, nto leyo eyabangela ukuba intsapho yakhe ifune unyango. Emva kokuxilongwa ngokucokisekileyo esibhedlele, kwafunyaniswa ukuba uYaoyao unesifo esibizwa ngokuba yi-systemic lupus erythematosus (SLE), esaziwa ngekhondo laso elintsonkothileyo nelingalindelekanga.
Ebudeni beminyaka emithathu, uYaoyao uye wafumana unyango olunzulu kunye nokulandelela rhoqo esibhedlele. Ngaphandle kokunyuka kweedosi zamayeza ezisondela kubuninzi bazo, imeko yakhe yabonisa ukuphucuka okuncinci. Ngokufanayo, i-proteinuria yakhe, isalathisi sokubandakanyeka kwezintso kwi-SLE, yaqhubeka ikhula, ibangela uxinzelelo kunye nokukhathazeka phakathi kwamalungu entsapho yakhe.
Ngokuthunyelwa komhlobo omthembileyo, u-Yaoyao waziswa kwiSibhedlele i-Lu Daopei, apho wathatha inxaxheba kulingo lwezonyango lwe-CAR-T. Ukulandela inkqubo yovavanyo olungqongqo, wamkelwa kwityala ngoAprili 8. Emva koko, ngoAprili 22, waya kuqokelelwa iiseli, kwaye ngoMeyi 12, wafumana ukufakwa kweeseli ezinyangwa yiCAR-T. Ukukhutshwa kwakhe ngempumelelo nge-27 kaMeyi kuphawule umzuzu obalulekileyo kuhambo lwakhe lonyango.
Ngexesha lokulandela kwakhe inyanga yokuqala, abaqeqeshi bezonyango babona inkqubela ebonakalayo, ukuncipha kweproteinuria. Kutyelelo olwalandelayo, irhashalala yolusu lwakhe yayiphantse yaphela, kwasala irhashalala nje esidleleni sasekunene. Okubaluleke kakhulu, i-proteinuria yakhe yayisombulule ngokupheleleyo, kwaye inqaku lakhe le-SLE Disease Activity Index (SLEDAI-2K) libonise imeko yesifo esincinci, esingaphantsi kwe-2.
Exhotyiswe kukusebenza konyango lweeseli zeCAR-T, uYaoyao ngokuthe ngcembe wawaphelisa amayeza akhe phantsi kweliso elibukhali likagqirha. Okumangalisayo kukuba, ebengawasebenzisi amayeza isithuba esingaphezulu kweenyanga ezine, engqina uxolelo oluqhubekayo oluphunyezwayo ngale ndlela yonyango isungulayo.
Uhambo luka-Yaoyao lugxininisa ukubanakho kwenguqu yonyango lwe-CAR-T ekulawuleni iimeko ezinzima zokuzikhusela komzimba njenge-SLE, enika ithemba kunye neziphumo ezibonakalayo apho unyango lwesintu lunokusilela. Amava akhe asebenza njengokukhanya kwethemba kwizigulana kunye neentsapho ezijonga imingeni efanayo, ebonisa ikamva elithembisayo leyeza lomntu kulawulo lwesifo somzimba.
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