Inkqubo yeLupus Erythematosus (SLE)-03
Ngo-Agasti 2016, uNksz A oneminyaka engama-20 ubudala wavelisa amabala amancinci abomvu kuwo wonke umzimba wakhe kunye nomkhuhlane oqhelekileyo, kwaye wayenezibalo eziphantsi zeplatelet, iinyanga ezisixhenxe emva kokubeleka. Emva kokuxilongwa izihlandlo ezininzi kwizibhedlele zasekuhlaleni, kwafunyaniswa ukuba une-systemic lupus erythematosus (SLE) kwisibhedlele sephondo. Ngo-Oktobha waloo nyaka, waqalisa ukufumana unyango kwisibhedlele sasekuhlaleni.
"Kwiminyaka esixhenxe edlulileyo, kwafuneka ndityelele esibhedlele rhoqo ngenyanga ukuze ndifumane imiyalelo, ukuhlolwa kwegazi rhoqo, ukuhlolwa komchamo, kunye namayeza rhoqo kunye neenaliti, kodwa imeko yayihlala iphindaphinda, eyayibuhlungu kakhulu," watsho uNksz A. Ezama ukunyanga isifo sakhe, umyeni wakhe wamsa kwizibhedlele ezininzi, kodwa iindleko eziphakamileyo azizange ziyizise isiqabu kwimeko yakhe. Ekugqibeleni, waba ne-lupus nephritis kunye ne-encephalopathy, kwaye ngoSeptemba 2022, wenziwa utyando lobuchopho. Ukuva ukuba unyango lwe-CAR-T lunokukwazi ukuphatha i-SLE, uNksz A wafuna uncedo kwisibhedlele sethu, apho iqela leengcali lihlalutye ngokukhawuleza imeko yakhe.
Ugqirha wachaza wathi, "Xa esi sigulana saqala ukungeniswa, sasine-edema eqhelekileyo, i-proteinuria ebalulekileyo, kunye ne-antibodies efanelekileyo. Wayefumene i-hormone yesintu kunye nonyango lwe-immunosuppressive, kunye nemijikelo esixhenxe zonyango lwebhayoloji, kodwa akukho nanye esebenzayo. Wenza i-lupus. i-encephalopathy, i-pulmonary hypertension, i-pulmonary fibrosis, kunye ne-renal biopsy yakhe yabonisa ukuba i-lupus esebenzayo. Xa kuthelekiswa nama-agent amachiza endabuko okanye ama-antibodies e-monoclonal, iiseli ze-CAR-T zinokungena kwizithintelo zezicubu, zisasaze ngokubanzi kwizicubu, kwaye zenze umphumo we-cytotoxic, ngokukodwa ngokuchasene neeseli ze-B okanye iiseli ze-plasma kwizithuba zezicubu ezingenakufikeleleka ngama-antibodies e-monoclonal. Ngaphandle ‘kwembewu yesifo,’ amajoni omzimba omguli aye ancipha ngokuthe ngcembe, amayeza abuyela kwimeko yesiqhelo, yaye iimpawu ngokuthe ngcembe zithomalalisa okanye ziphele.” Ngoko ke, umguli walufumana ngempumelelo unyango lweCAR-T.
UNksz A wathi, "Ngoku amabala abomvu emzimbeni wam aphelile, kwaye andisafuni amayeza e-hormone okanye i-immunosuppressants. Ndandisoloko ndihlola igazi kunye nomchamo, kodwa ngoku ndifuna kuphela emva kweenyanga ezintandathu. Imeko yam yonke kuhle, kwaye zonke izikhombisi ziqhelekile namhlanje lutyelelo lwam lwesithathu, kwaye iziphumo zotyelelo lwangaphambili bezilungile. Ndinombulelo ongazenzisiyo kubasebenzi bezonyango ngokundinika ithuba lesibini ebomini.
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