Inkqubo yeLupus Erythematosus (SLE)-01
U-Xiaohuan oneminyaka engama-24 ubudala ufundela ubugqirha eyunivesithi iminyaka emithathu kwaye ukhathazwa yi-systemic lupus erythematosus (SLE) phantse iminyaka eli-10. “Ndafunyaniswa ndineminyaka eli-10 ubudala, kwaye ugqirha wathi kunzima kakhulu ukunyanga, ukuba ndingalawula kuphela ngamayeza,” utshilo uXiaohuan ngoncumo olukrakra. Kule minyaka ilishumi idlulileyo, bekufuneka aye kukhangelwa inyanga nenyanga kunye nemiyalelo kagqirha, kwaye wafumana unyango lwehomoni, unyango lwe-immunosuppressive, kunye nonyango lwebhayoloji, kodwa alukho olusebenzayo. Wanyamezela ukulahleka kweenwele ezinzulu, amaqhakuva amaninzi, umkhuhlane ophindaphindiweyo, kunye neentlungu ezixhaphakileyo.
Emva kovavanyo lokuqala olwahlukeneyo, u-Xiaohuan wadibana nazo zonke iikhrayitheriya zonyango lwe-CAR-T ye-SLE. Iqela leengcali ngobuchule lenze isicwangciso sonyango ngokusekelwe kwimeko yakhe kwaye ilungiselelwe ngononophelo inkqubo yokuqokelela iiseli. Ngomhla wama-28 kaMatshi, ingqokelela yeeseli ze-mononuclear yaqala. Nge-22 ka-Epreli, waqala i-lymphodepleting chemotherapy. Ngomhla wama-28 ka-Epreli, izisele zaphinda zafakwa. Iiseli ze-T ezizizigidi ezingamashumi amabini ze-CAR zifakwe ngokuthe chu kwi-vein ye-Xiaohuan, zijolise ngokuthe ngqo kwiiseli ze-lupus B, ziqalisa "uhlaselo oluchanekileyo, lwaphule enye nganye".
Ngomhla we-4 kaJuni, umhla we-38 emva kokufakwa, u-Xiaohuan wabuyela esibhedlele ukuze alandele. Iziphumo zeemviwo zibonise ukuba zonke izalathisi ezibaluleke kakhulu ziye zehla zaya kuluhlu oluqhelekileyo. “Andisafuni amayeza ehomoni; kuvakala ngathi ubomi buyaqala,” utshilo uXiaohuan ngovuyo.
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