Unyango lweeseli ze-NS7CAR-T lubonisa isithembiso sokuNyanga i-R/R T-ALL/LBL

Upapasho lwakutsha nje kwijenali Igazi lizise ingqwalasela ebalulekileyo kunyango lweseli ye-NS7CAR-T yokunyanga i-T-cell acute lymphoblastic leukemia (R/R T-ALL) kunye ne-T-cell lymphoblastic lymphoma (R/R T). -LBL). Uphononongo, olwenziwa njengesigaba soku-1 solingo lwezonyango (ClinicalTrials.gov: NCT04572308), luvavanye ukhuseleko kunye nokusebenza kolu nyango lutsha.

Ulingo lwalubandakanya izigulane ezine-R / R T-ALL / LBL ezifumene iiseli ze-NS7CAR-T. Iziphumo zabonisa ukuba unyango lwe-NS7CAR-T alukhuselekanga nje kuphela kodwa lukwabonise umsebenzi onomtsalane wokuchasana nethumba. Izigulana ezinyangwe ngeeseli ze-NS7CAR-T zibonise iimpendulo ezibalulekileyo zeklinikhi, zicebisa ukuba olu nyango lunokubakho njengesixhobo esinamandla ngokuchasene nale mingeni yomhlaza.

Abaphandi emva kophando baquka iqela leengcali ezivela kwiSibhedlele saseHebei Yanda Lu Daopei kunye neHebei Senlang Biotechnology Co., Ltd. Iziphumo zabo zibonisa ukuba iiseli ze-NS7CAR-T ziyakwazi ukuveliswa ngokufanelekileyo ngaphandle kokuguqulwa kofuzo olongezelelweyo ukukhusela ukubonakaliswa kwe-CD7, ukulungelelanisa inkqubo yokuvelisa. kunye nokuphucula ukusebenza konyango.

Le mpumelelo kwi-NS7CAR-T yonyango lweeseli ihambelana neenzame eziqhubekayo zokuphuhlisa unyango olusebenzayo lwe-T-ALL kunye ne-T-LBL. Inkampani yethu ikwaqhubela phambili kweli candelo ngemveliso yethu ye-CAR-T, esikholelwa ukuba iya kuhambelana neziphumo ezithembisayo ezibonwe ngonyango lwe-NS7CAR-T.

Iziphumo ezikhuthazayo zolu phononongo zivula indlela yophando olongezelelweyo kunye nezilingo zeklinikhi zokuqinisa indima yeeseli ze-NS7CAR-T ekunyangeni i-T-cell malignancies ebuyele emva okanye echasayo. Njengoko ulwazi oluninzi lufumaneka, kuyathenjwa ukuba olu nyango kungekudala luya kuba lukhetho oluqhelekileyo kwizigulana ezilwa nezi zifo zihlaselayo.