Unyango lwe-CD19 CAR-T lweSibhedlele saseLu Daopei lubonisa iziphumo ezithembisayo kwi-B-ALL izigulana
Kuphononongo olusisiseko oluqhutywe kwiSibhedlele saseLu Daopei, abaphandi baye bachaza inkqubela phambili ebalulekileyo kunyango lwe-refractory okanye i-relapsed B acute lymphoblastic leukemia (B-ALL) usebenzisa i-CD19-directed CAR-T cell therapy. Uphononongo, olubandakanya izigulane ze-51, lubonise ukuba le ndlela yokuvuselela ayizange iphumelele kuphela amazinga aphezulu okuxolelwa (CR) kodwa igcine iprofayili yokhuseleko olufanelekileyo.
Iqela lophando, elikhokelwa nguDkt C. Tong ovela kwiSebe le-Hematology kunye noDkt AH Chang ovela kwiZiko loPhando lweClinical Translational kwi-Tongji University School of Medicine, uphando ngemiphumo yokulawula umthamo ophantsi weeseli ze-CAR-T-malunga ne-1. × 10 ^ 5 / kg-xa kuthelekiswa namanani aphezulu aqhelekileyo. Le ndlela ijolise ekulinganiseni ukusebenza konyango kunye nokunciphisa iziphumo ezibi kakhulu, ngakumbi i-cytokine release syndrome (CRS).
Iziphumo zophononongo bezinyanzelisa. Phakathi kwe-42 ye-refractory / i-relapsed B-ALL izigulane, i-36 iphumelele i-CR okanye i-CR kunye nokubuyiswa kwesibalo esingaphelelanga (i-CRi), ngelixa zonke izigulane ezisithoba ezinesifo esincinci se-residual (MRD) zafikelela kwi-MRD negativity. Ngaphaya koko, uninzi lwezigulana ziye zafumana i-CRS ephakathi ukuya kwimodareyitha kuphela, iimeko ezimandundu zilawulwa ngokufanelekileyo ngezicwangciso zongenelelo lwakwangoko.
UGqr. Tong ugxininise ukubaluleka kolu phononongo, esithi, "Iziphumo zibonisa ukuba i-CD19 CAR-T cell therapy enedosi ephantsi, elandelwa yi-allogeneic hematopoietic stem cell transplantation (allo-HCT), inika unyango olusebenzayo kakhulu kwizigulane ezine iindlela ezizezinye ezilinganiselweyo Olu nyango alunikezeli kuphela amazinga aphezulu okuphendula kodwa luthoba kakhulu umngcipheko weziphumo ezibi kakhulu.
Impumelelo yolu phononongo igxininisa amandla okunyangwa kweeseli ze-CAR-T ekuphatheni i-hematological malignancies. Isibhedlele saseLu Daopei, esidume ngomsebenzi waso wobuvulindlela kwi-cellular immunotherapy, siyaqhubeka nokukhokela ekuboneleleni ngonyango olukumgangatho ophezulu kwizigulana ezinocelomngeni lwe-hematologic.
Njengoko uphando luqhubela phambili, iqela lophando linethemba malunga nokucokisa ngakumbi idosi kunye nemigaqo yokuphucula iziphumo zesigulana. Iziphumo zolu phononongo zipapashwe kwijenaliIgazi legazikunye nokubonelela ngethemba elithemba kwizigulane ze-B-ZONKE kwihlabathi jikelele.