Ukusebenza kwexesha elide kweCD19 CAR T-Cell Therapy kuNyango oluBuyelweyo/ oluRefractory Acute Lymphoblastic Leukemia
Kwinkqubela phambili ebalulekileyo kwinkalo ye-hematology, uphononongo lwakutsha nje luye lwaqaqambisa ukusebenza kwexesha elide kweCD19 chimeric antigen receptor (CAR) T-cell therapy kwizigulana ezinesifo se-acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem. ukutshintshwa kweseli (i-allo-HSCT). Uphononongo, olulandela izigulane kwixesha elongeziweyo, lunika uhlalutyo olubanzi lweziphumo, lubonelela ngeembono ezixabisekileyo malunga nokuqina kunye nokhuseleko lonyango olutsha.
Uphononongo lulandele ngononophelo izigulane ezaye zafumana unyango lwe-CD19 CAR T-cell emva kokufumana ukuphinda ZONKE okulandela i-allo-HSCT. Iziphumo zithembisa, zibonisa ukuba inxalenye ebalulekileyo yezigulane zifumene ukuxolelwa okupheleleyo, kunye neempendulo eziqhubekayo ezibonwe kwiminyaka. Olu phando alugxininisi kuphela amandla onyango lwe-CAR T-cell therapy kodwa lubonisa isiganeko esibalulekileyo kunyango lwe-hematological malignancies, ngakumbi abo banokhetho oluncinci zonyango.
Ngaphaya koko, uphononongo luphonononga kwiprofayili yokhuseleko lonyango, ukunika ingxelo ngeziphumo ebezingalindelekanga ezilawulekayo, ebezingqinelana neziphumo zangaphambili. Oku kuqinisa ukuzithemba okukhulayo kwi-CAR T-cell therapy njengonyango olusebenzayo kunye nolusebenzayo lokubuyisela kwakhona / ukuchasa BONKE, ngakumbi kwimeko yokutshintshwa.
Njengoko intsimi ye-immunotherapy iqhubeka nokuvela, olu phononongo lusebenza njengebhakana yethemba kwizigulane kunye nababoneleli bezempilo ngokufanayo, bethembisa ikamva apho izigulana ezininzi zinokufezekisa ukuxolelwa kwexesha elide. Iziphumo azikho nje igalelo kumzimba okhulayo wobungqina obuxhasa unyango lwe-CAR T-cell kodwa kwakhona uvula indlela yophando olongezelelweyo lokwandisa kunye nokwandisa ukusetyenziswa kwayo kwimimiselo yeklinikhi.
Ngale mpumelelo, uluntu lwezonyango lusondela ekuguquleni indawo yonyango lwe-hematological malignancies, enika ithemba elitsha kwizigulana ezisilwa nezi meko zinzima.