UNyango lweeSeli ze-CAR-T ezintsha luguqula unyango lwe-B Cell Malignancies
Kuphononongo lwakutsha nje olupapashwe kwiJenali yeZiko loMhlaza weSizwe, iingcali ezivela kwiSibhedlele saseLu Daopei, ekhokelwa nguDkt Peihua Lu, kunye nabasebenzisana nabo kwiYunivesithi yaseTexas MD Anderson Cancer Centre, bakhanyisela intuthuko yakutshanje kwi-CAR-T. Iiseli zonyango kunyango lwe-B-cell malignancies. Olu phononongo lubanzi luxoxa ngeendlela ezininzi ezintsha, kubandakanywa ukuvela koyilo lweseli ye-CAR-T kunye nokudityaniswa kweeseli zonyango, ukuphucula ukusebenza kunye nokhuseleko lonyango lwezifo ezifana ne-non-Hodgkin's lymphoma (NHL) kunye ne-acute lymphoblastic leukemia (YONKE). ).
I-B-cell malignancies ibeka imingeni ebalulekileyo ngenxa yokuthambekela kwabo ukubuyela kwakhona kunye nokuphuhlisa ukuchasana nonyango oluqhelekileyo. Ukuqaliswa kwe-chimeric antigen receptor (i-CAR) iiseli ze-T ziye zatshintsha indawo yonyango, enika ithemba elitsha kwizigulane ezijongene nala ma-cancer anobudlova. Uphononongo luqaqambisa indlela iiseli ze-CAR T ezinokuthi zenziwe ngobunjineli kunye nezizukulwana ezininzi zoyilo, zibandakanya iimpawu eziphambili ezifana ne-bispecific receptors kunye neendawo ezixabisayo, ukuze zijolise ngokufanelekileyo kwiiseli zethumba kunye nokunciphisa ukuba nokwenzeka kokubuyela kwakhona.
Isibhedlele saseLu Daopei siye sahamba phambili kwi-CAR-T yophando lweseli kunye nesicelo seklinikhi, ebonisa impumelelo ephawulekayo ekudaleni ukuxolelwa kwexesha elide. Ukubandakanyeka kwesibhedlele kulo msebenzi wobuvulindlela kugxininisa ukuzinikela kwaso ekuqhubeleni phambili unyango lomhlaza kunye nokubonelela ngokhathalelo lwangoku. Uphononongo luphinda luhlolisise amandla okudibanisa unyango lwe-CAR-T kunye nolunye unyango, olufana ne-immunotherapy kunye nonyango olujoliswe kuyo, ukunqoba iindlela zokuchasa kunye nokuphucula iziphumo zesigulane.
Olu papasho lububungqina bemigudu yentsebenziswano yabaphandi bamazwe ngamazwe kunye neekliniki ekutyhaleni imida yonyango lomhlaza. Iziphumo zibonelela ngokukrobisa kwikamva le-oncology echanekileyo, apho unyango olulolwakho kunye nolwenziwa ngokutsha lunokuguqula ubomi bezigulane ezilwa neeseli ze-B. Igalelo leSibhedlele iLu Daopei kulo mmandla lisibane sethemba, liqhuba uphuhliso lonyango olukhuselekileyo nolusebenzayo ngakumbi lomhlaza.