Ukomelezwa kokuSebenza kwe-Antitumor ye-4-1BB-Isekelwe kwi-CD19 ye-CAR-T yeeSeli ekuNyangweni kwe-B-ALL

Kuphononongo olubalulekileyo lweklinikhi olwenziwa siSibhedlele iLu Daopei kunye neLu Daopei Institute of Hematology, abaphandi bafumanise ukuba iiseli ze-CD19 CAR-T ezisekwe kwi-4-1BB zibonelela ngenye indlela ethembisayo kwiiseli ze-CD28 ezisekwe kwi-CAR-T ukuze kunyangelwe ukubuyisela umva okanye ukuchasa. I-B cell acute lymphoblastic leukemia (r / r B-ALL). Olu phononongo, olubandakanya uphando olunzima lwangaphambi kweklinikhi kunye nophando lweklinikhi, lubonise ukuba iiseli ze-4-1BB ze-CAR-T aziboneleli kuphela ngokusebenza okuphezulu kwe-antitumor kodwa zibonise ukuzingisa kwexesha elide kwizigulane xa kuthelekiswa ne-CD28 esebenza nabo.

Iqela lophando leSibhedlele i-Lu Daopei lithelekise ngokucokisekileyo ukusebenza kwezi ntlobo zimbini zeeseli ze-CAR-T. Baye bafumanisa ukuba, phantsi kwenkqubo efanayo yokuvelisa, iiseli ze-4-1BB ze-CAR-T zinempembelelo enamandla kakhulu ye-antitumor kwi-dose ephantsi kwaye ibangele iziganeko ezimbi ezibi kakhulu kuneeseli ze-CD28 ze-CAR-T. Iziphumo zophononongo zibonisa ukuba unyango lwe-CAR-T olusekwe kwi-4-1BB lunokubonelela ngonyango olusebenzayo nolukhuselekileyo kwizigulane ezine-r/r B-ALL.

Ezi ziphumo zigxininisa ukuzinikela kweSibhedlele i-Lu Daopei ekuqhubeleni phambili i-hematology kunye ne-immunotherapy, enika ithemba kwizigulane ezingakhange ziphendule kunyango oluqhelekileyo. Uphononongo, olwalandela imilinganiselo yokuziphatha engqongqo lwaza lwavunywa yiKomiti yeeNdlela zokuziphatha zeSibhedlele saseLu Daopei, lugxininisa indima yesibhedlele ekukhokeleni kuphando olutsha kunyango lweeseli zeCAR-T.

Ngale mpumelelo, iLu Daopei Institute of Hematology iyaqhubeka nokuba nguvulindlela kwimida emitsha kuphando lwezonyango, ibonelela ngeendlela zonyango ezikumgangatho ophezulu kunye nokuphucula iziphumo zesigulana. Le nkqubela phambili ibubungqina bokuzinikela nobuchule bamaqela ezonyango nophando eSibhedlele iLu Daopei.