I-Bioocus iqhubela phambili kwi-Frontier kuNyango lwaBantwana lwe-Acute Lymphoblastic Leukemia
Isiganeko esibalulekileyo kwintsimi ye-CAR-T yonyango, ephawulwe ngokupapashwa kwakutshanje kophando olusisiseko olukhokelwa nguDkt Chunrong Tong kwisibhedlele saseLu Daopei. Uphononongo, olunesihloko esithi "Amava kunye neMingeni yeSizukulwana seSibini iCD19 CAR-T Cell Therapy in Pediatric Acute Lymphoblastic Leukemia," inika uhlalutyo olubanzi lokusebenza kunye nokhuseleko lwesizukulwana sesibini sonyango lweseli yeCD19 CAR-T kunyango lwabantwana lwe-lymphoblastic leukemia. (BONKE).
Olu phando lugxininisa amandla okuvelisa izinto ezintsha ze-Bioocus's CAR-T imveliso ekujonganeni neyona meko ingumceli mngeni ye-hematological ebantwaneni. Uphononongo luchaza ngokubanzi iziphumo zeklinikhi eziqatshelwe kwizigulane eziye zafumana olu nyango, zityhila amazinga athembisayo oxolelo. Nangona kunjalo, iphinda ichonge imingeni enzima, ngakumbi ulawulo lwe-cytokine yokukhululwa kwe-syndrome (CRS) kunye ne-neurotoxicity, ehlala iindawo eziphambili zokugxila ekuphuculeni ukhuseleko lwesigulane.
Unyango lwe-CAR-T lwe-Bioocus, oluboniswe kolu phononongo, luxhasa uyilo lwesizukulwana sesibini esonyusa umsebenzi we-T-cell ngokuchasene neeseli zomhlaza ezichaza i-antigen ye-CD19. Le ndlela ibaluleke kakhulu ekoyiseni iindlela zokuxhathisa ezihlala zidibana nonyango lwabantwana olubuyela umva okanye oluchasayo ZONKE iimeko. Iziphumo ezithiwe thaca kolu papasho azigqamisi nje kuphela amandla onyango emveliso ye-Bioocus ye-CAR-T kodwa ikwagxininisa ukubaluleka kobuchule obutsha obuqhubekayo kunye nophando lweklinikhi ukucokisa olu nyango ngakumbi.
Uphando lukaGqr. Tong lufaka igalelo kwiimbono ezixabisekileyo ekusetyenzisweni kwe-CAR-T yonyango kwaye ihambelana nomsebenzi we-Bioocus wokuqhubela phambili unyango lomhlaza ngokusebenzisa izisombululo ze-biotechnological. Njengomkhokeli wehlabathi kuphuhliso lwe-CAR-T, i-Bioocus ihleli izimisele ukutyhala imida yento enokwenzeka kunyango lomhlaza, ngenjongo yokugqibela yokuphucula iziphumo zesigulane kunye nomgangatho wobomi.
Njengoko i-Bioocus iqhubeka nokusebenzisana namaziko ezonyango aphambili afana neSibhedlele saseLu Daopei, sihlala sizinikele ekujonganeni nemingeni echongiweyo kolu phononongo kunye nokucokisa iimveliso zethu ze-CAR-T ukuphucula ukhuseleko kunye nokusebenza kwazo. Ukuzibophelela kwethu ekugqweseni nasekuveliseni izinto ezintsha kuqinisekisa ukuba sikwindawo entle yokukhokela ikamva lonyango lomhlaza.