I-Myasthenia gravis-01

Ibali loNyango lukaZhang Wei lweMyasthenia Gravis

UZhang Wei, injineli yesoftware eneminyaka engama-32 ubudala, waqala ukufumana iimpawu ze-myasthenia gravis (MG) kwiminyaka emibini edlulileyo. Ekuqaleni, wayene-ptosis (iinkophe ezithobileyo) kunye nokubona luzizi, kodwa iimpawu zakhe zaba mandundu ngokuhamba kwexesha, nto leyo eyakhokelela kubuthathaka obuqhelekileyo bezihlunu obachaphazela kakhulu umsebenzi wakhe nobomi bemihla ngemihla. Nangona wayefumana unyango olwahlukahlukeneyo, kuquka amayeza e-anticholinesterase, amayeza akhusela umzimba omzimba, kunye ne-intravenous immunoglobulin, iimpawu zakhe zaqhubeka kwaye ziphindaphinda.

Ngonyango lwesintu lubonakala lungasebenzi, oogqirha bacebise ukuba uZhang Wei azame indlela entsha yonyango: Unyango lweeseli zeCAR-T. Olu nyango lunenguqulelo entsha lusebenzisa ubunjineli bemfuza ukuguqula iiseli ze-T zesigulana, nto leyo ezenza zikwazi ukujolisa nokuphelisa iiseli ezingaqhelekanga ezinxulumene nesi sifo.

Emva kophononongo olucokisekileyo, uZhang Wei wabonwa efanelekile kunyango. Oogqirha baqala bakhetha iiseli ze-T emzimbeni wakhe baza batshintsha imizila yemfuza baza bazandisa elabhoratri. U-Zhang Wei emva koko wenza i-chemotherapy ye-conditioning ukunciphisa inani le-lymphocytes ekhoyo emzimbeni wakhe, elungiselela ukuqaliswa kweeseli ze-CAR-T. Ekugqibeleni, iiseli ze-CAR-T ezilungisiweyo zabuyiselwa kumzimba kaZhang Wei.

Ngexesha lokuqala lonyango, uZhang Wei wafumana ukudinwa okufutshane, kodwa kwiiveki ezimbini kamva, iimpawu zakhe zaqala ukuphucuka kakhulu. I-ptosis kunye nombono okhanyayo zancitshiswa ngokuphawulekayo, kwaye amandla akhe ngokuthe ngcembe abuyela. Kwinyanga kamva, ukusebenza kakuhle kwakhe kwaphucuka, yaye wayenokuphinda aqalise imisebenzi eqhelekileyo yemihla ngemihla. Kwiinyanga ezintathu emva konyango, iimpawu zikaZhang Wei zaziphantse zanyamalala, kwaye wayengasawadingi amayeza angaphambili. Iimvavanyo ezilandelelweyo zabonisa ukuba inkqubo yakhe yomzimba yokuzikhusela yayikwimeko entle, kungekho miphumo mibi okanye iimpawu zokubuya kwesifo.

Ngonyango lweeseli ze-CAR-T, i-myasthenia gravis kaZhang Wei yalawulwa kakhulu, iphucula kakhulu umgangatho wobomi bakhe kunye nokukwazi kwakhe ukusebenza. Olu nyango lunika ithemba elitsha kwizigulane ezininzi ze-myasthenia gravis.