IiMyeloma ezininzi ezine-Extramedullary Plasmacytoma

Le yimeko yesigulane esineminyaka engama-73 ubudala esifunyanwe sine-myeloma eninzi, inzima kubukho be-extramedullary plasmacytoma. Kulo lonke ixesha lonyango kunye neDara-VRD (iDaratumumab, i-Bortezomib, iLenalidomide, i-Dexamethasone), i-plasmacytoma ye-extramedullary yaqhubeka, ibangela intlungu enkulu kunye nokukhathazeka kwisigulane.

Ukuqwalasela ubundlongondlongo besi sifo kunye nokungabikho kokuphendula kunyango oluqhelekileyo, isigulane sabhaliswa kwilingo lonyango lwe-BCMA CAR-T cell cell. Emva kokuthatha amanyathelo afunekayo okulungiselela, kubandakanywa ne-lymphodepletion, isigulane safumana ukunyuswa kweeseli ze-BCMA CAR-T.

Okuphawulekayo kukuba, kwiintsuku ze-10 emva kokuxilwa, isigulane safumana impendulo ye-second-degree cytokine release syndrome (CRS), ebonisa ukusebenza okunamandla komzimba. Ukongeza, bekukho i-CRS ebalulekileyo yendawo kwindawo ye-plasmacytoma ye-extramedullary.

Okumangalisa nangakumbi kukuba kweli xesha lifutshane, isilonda se-extramedullary esinganyangekiyo ngaphambili, esasingqineke simelana nemizila emininzi yechemotherapy, amayeza ekujoliswe kuwo, kunye nezilwa-buhlungu zemonoclonal, zanyamalala ngokupheleleyo. Isigulane siphumelele ukuxolelwa okupheleleyo, ukuphawula impumelelo yonyango.

Kuyo yonke inkqubo yonyango, iqela lezonyango libeke iliso elibukhali isigulane kuzo naziphi na iimpawu zokusabela kakubi kwaye linike ukhathalelo olubanzi lwenkxaso. Oku kubandakanya ukulawula iimpawu zeCRS kunye nokujongana nazo naziphi na ezinye iingxaki ezinxulumene nonyango.

Njengoko unyango luqhubela phambili, iqela lezonyango laqhubeka libeka iliso ngokusondeleyo impendulo yesigulane kwi-BCMA CAR-T yonyango lweseli. Uvavanyo lwarhoqo lwenziwa ukuvavanya ukusebenza konyango kunye nokujongana nazo naziphi na iziphumo ebezingalindelekanga ezivelayo ngokukhawuleza.

Ukulandela impumelelo ephawulekayo yokuxolelwa okupheleleyo, umgangatho wobomi besigulane uphuculwe kakhulu, kunye nokukhululeka kweentlungu kunye nokukhathazeka okuhambelana ne-plasmacytoma ye-extramedullary. Ngesi sifo siphantsi kolawulo, isigulana sikwazile ukuphinda siqalise imisebenzi yemihla ngemihla kwaye sonwabele impilo engcono.

Ngaphezu koko, ngokuqonda ukubaluleka kokhathalelo olulandelelweyo lwexesha elide, iqela lethu lezonyango lahlala libandakanyeka ngokukhutheleyo kuhambo lwasemva konyango lwesigulane. Ukuqeshwa okulandelwa rhoqo kwacwangciswa ukubeka iliso kwimeko yesigulane, ukuvavanya ukuqina kwempendulo yonyango, kunye nokujongana nayo nayiphi na imiphumo enokubakho okanye imiphumo emibi.

Ukongeza kulandelelwano lwezonyango, iziko lethu libonelele ngeenkonzo zenkxaso ezibanzi ukunceda isigulana ukuba silungelelanise nobomi emva konyango. Oku kubandakanya ukufikelela kwiinkonzo zokucebisa, iinkqubo zokubuyisela kwisimo sangaphambili, kunye nezibonelelo zemfundo ukunceda isigulane kunye nosapho lwabo ukuba baqhubele phambili ukusinda kunye nokugcina indlela yokuphila enempilo.

Isiphumo esiyimpumelelo sale meko asibonisi nje kuphela ukusebenza kwe-BCMA CAR-T yonyango lweeseli ekuphatheni i-myeloma ephindaphindayo kodwa iphinda iqaqambise ukubaluleka kokhathalelo lomntu ngamnye kunye nolwabantu abaninzi ekulawuleni i-hematological malignancies. Ukuzinikela kwethu ekuboneleleni ngenkxaso eqhubekayo kunye nokunyamekela okulandelwayo kubonisa ukuzinikela kwethu ekuqinisekiseni iziphumo ezingcono kakhulu kwizigulane zethu ngaphaya kwesigaba sonyango.

Ngaphambi kunye neenyanga ezi-3 emva kokufakwa