I-Multi-Resistant Diffuse Large B-cell Lymphoma (DLBCL)

UMnu X, isigulana esiyindoda, enikezelwe nge-multi-line resistant diffuse enkulu ye-B-cell lymphoma (DLBCL), imeko enzima ebonakaliswe ngokuxhathisa kwethumba kwimigca emininzi yonyango. Ekuvavanyeni kokuqala, uMnu X wakhalaza ngeentlungu ezibuhlungu zesisu, ebangela uphando olongezelelweyo.

Izifundo zokucinga, ezibandakanya i-Figure 1, zibonakalise ubunzima obukhulu kwisigxina sesisu, esibonisa ukubandakanyeka kwezifo ezinzulu. Ubukho bobunzima obunjalo abuzange bube negalelo ekubeni uMnumzana X akhathazwe sisisu nje kuphela, kodwa kwabangela ukuba axhalabe ngokuqhubekayo nokuba ndlongondlongo kwelymphoma yakhe.

Ukuqwalasela impumelelo elinganiselweyo yemigca yonyango yangaphambili kunye nesidingo esiphuthumayo sokungenelela okusebenzayo, uMnu X wabhaliswa kwilingo lonyango lwe-CD19 + 22 CAR-T cell therapy. Emva kokuthatha amanyathelo afunekayo okulungiselela, kubandakanywa nokunyangwa kwangaphambili, uMnu X wafumana ukunyuswa kweeseli ze-CD19 + 22 ze-CAR-T.

Ngokuphawulekayo, i-Figure 2, ethathwe kwiinyanga ezintathu emva kokubuyisela ukunyuswa kweeseli ze-CD19 + 22 ze-CAR-T, zibonise ukunyamalala ngokupheleleyo kwesisu esiswini. Le mpendulo iphawulekayo kunyango ibonise umphumo oyimpumelelo, kunye ne-lymphoma yapheliswa ngokufanelekileyo.

Kulo lonke uhambo lwakhe lonyango, uMnu. X wafumana ukhathalelo olubanzi kunye nenkxaso kwiqela lezonyango. Oku kuquka ukujongwa ngokusondeleyo kwemeko yakhe, ulawulo lweziphumo ebezingalindelekanga ezinxulumene nonyango, kunye nenkxaso yeemvakalelo ukumnceda amelane nemingeni yokulwa nomhlaza.

Ukongezelela, ngaphaya kokunakekelwa kwezonyango, sinikeze uMnu X uluhlu lweenkonzo zokuqinisekisa impilo yakhe yonke ngexesha lokunyanga kwakhe. Oku kwakuquka ukumlungiselela indawo yokuhlala etofotofo, ukubonelela ngokutya okunesondlo okuhambelana neemfuno zakhe zokutya, ukulungiselela isithuthi sokuya kuqeshwa kunye neemfuno zohambo, kunye nokunika inkxaso ngokwasengqondweni kuye nentsapho yakhe ukuze abancede bakwazi ukutyhubela eli xesha linzima.

Ityala likaMnu X ligxininisa amandla onyango olutsha olufana ne-CAR-T ye-cell therapy ekoyiseni i-DLBCL ye-multi-line resistant. Igxininisa ukubaluleka kophando oluqhubekayo kunye nophuhliso kwinkalo ye-oncology ukubonelela ngethemba kunye neendlela zonyango ezisebenzayo kwizigulane ezijongene nobunzima bokunyanga i-cancer njenge-DLBCL.

Ngaphambi kunye neenyanga ezi-3 emva kokufakwa