FAQ-Unyango

Q.
Yintoni utyando lwegazi kunye nomongo wethambo (BMT)?

A.

Ukutshintshwa kwegazi kunye namathambo luhlobo olukhethekileyo lonyango kubantu abaneentlobo ezithile zomhlaza okanye ezinye iingxaki zethambo. Kwigazi kunye nokufakelwa komongo wethambo, iiseli eziqhelekileyo ezifumaneka kumongo wethambo zithathwa, zilungiswe kwaye zibuyiselwe kwisigulane okanye komnye umntu. Injongo yofakelo-gazi kunye nomongo wethambo kukunika umntu iiseli zomongo osempilweni emva kokuba owawo umongo wethambo ususiwe.

Utyando lwegazi kunye nomongo wethambo luye lwasetyenziswa ngempumelelo ukususela ngo-1968 ukunyanga izifo ezifana ne-leukemia, i-lymphoma, i-aplastic anemia, ukuphazamiseka kwe-immunodeficiency kunye nomhlaza wethumba eliqinileyo.
Q.
Lithini ixesha eliqikelelweyo lokuhlala esibhedlele kwi-BMT?

A.
Kuqikelelwa ukuba uqhaqho-fakelo umongo wethambo uhlala esibhedlele malunga neeveki ezi-4-6. Nangona kunjalo, kuya kufuneka ukuba uhlale ngaphakathi kwesixeko kangangeenyanga ezi-6 ubuncinane njengoko ulandelelo lwe-BMT rhoqo lufuneka.
Q.
Ngubani onokuzuza kwigazi kunye noqhaqho lomongo (BMT)?

A.
Ezi zifo zilandelayo zezona zixhaphakileyo ukuba zixhamle kwigazi okanye ukufakelwa umongo wethambo:

- Leukemias

- I-anemia ye-aplastic enzima

- Lymphomas

- Myeloma ezininzi

- Izifo zokunqongophala kwamajoni omzimba
Q.
Yintoni unyango lwe-CAR-T?

A.
I-Chimeric antigen receptor T (CAR-T) unyango lweseli lunyango olutsha kwiindidi ezahlukeneyo zomhlaza. Ingcamango kukususa iiseli ze-T zesigulana kunye ne-genetically engineer them to express chimeric antigen receptor (CAR) eqaphela i-antigen ethile ehambelana ne-tumor (TAA). Ngenxa yoko, xa i-CAR-ebonisa i-T-cells iphinda ifakwe emzimbeni wesigulane, iya kujolisa kwaye ikhuphe iiseli ze-tumor ezibonisa i-TAA.
Q.
Zeziphi izigulana ezixhamlayo kwiCAR-T?

A.
Ulingo lwezonyango lwe-CAR-T lenzelwe izigulane ezine-B-cell acute lymphoblastic leukemia (B-ALL), i-B-cell lymphoma kunye ne-myeloma ezininzi eziye zaphinda zabuyela okanye zichasa kwi-chemotherapy.
Q.
Kufuneka sihlale ixesha elingakanani esibhedlele kwi-CAR-T?

A.

Ulingo lwezonyango lwe-CAR-T luthatha malunga neeveki ezi-6-8, oko kuxhomekeke kwimeko yesigulane ngasinye.
Q.
Yintoni inkqubo yonyango ye-CAR-T?

A.
Q.
Zingaphi iCAR-T osele uzenzile?

A.
Ukususela ngo-2015, siye sagqiba malunga ne-300 izilingo zekliniki ze-CAR-T ze-refractory relapsed B-ALL, i-B-cell lymphoma kunye ne-myeloma eninzi eneziphumo ezibalaseleyo. Sishwankathele iimeko zokuqala ezingama-51 kwaye sazipapasha kwiJenali yeLeukemia ngo-2017.
Q.
Lithini izinga lakho le-CAR-T lempumelelo?

A.
Ireyithi yoxolelo epheleleyo iyonke ibingaphezulu kwama-90%.
Q.
Iyintoni inzuzo yokuba ne-bone marrow transplant (BMT) emva kwe-CAR-T?

A.
Nangona izinga loxolelo olupheleleyo (CR) lonyango lwe-CAR-T liphezulu, kusekho umngcipheko wokuphinda ubuyele. Uphononongo lubonise ukuba ukuvala i-BMT emva kwe-CAR-T ye-B-ALL kunokunyusa ngakumbi izinga lokunyanga elinokubakho.
Q.
Ndilifumana njani idinga?

A.
Ungafumana idinga ngokusebenzisa abameli bethu bamazwe ngamazwe.
Q.
Ngawaphi amaxwebhu ekufanele ndize nawo?

A.
Kubaluleke kakhulu ukuba ngelixa uhambayo ube nawo onke amaxwebhu afanelekileyo akhoyo kunye nawe kubandakanya ikopi eprintiweyo yazo zonke iingxelo zonyango, iingxelo zezifo ezibandakanya izilayidi zeglasi kunye neebhloko zeparafini eziya kufunwa ukuphononongwa, iziphumo zemifanekiso yeCT, MRI, PET- I-CT scan,inkqubo yegazi, i-immune histochemistry, uvavanyo lwemfuzo, iziphumo zechromosome ukuba zikhona.
Q.
Ngubani oza kujongana namadinga am kunye neshedyuli ngelixa ndisesibhedlele?

A.
Iqela lethu lamazwe ngamazwe liza kubhukisha amadinga kwaye likucwangcisele ukulandelelwa ngelixa usesibhedlele.
Q.
Yintoni inkqubo yokuba izigulana zifune iingcebiso zonyango?

A.
Abasebenzi bethu beZiko laMazwe ngaMazwe bajonge ukubonelela ngofikelelo olulungelelanisiweyo kunye nokhathalelo lobuqu lwezigulane zethu zamazwe ngamazwe. Abasebenzi bethu baya kufumaneka ukuze bancede zonke izigulane kuwo onke amanqanaba okhathalelo lwazo.
Q.
Ndingayifumana ingxelo yetyala lam emva konyango?

A.
Ewe, emva konyango, siya kuguqulela ingxelo yetyala lakho kwaye sikunike ingxelo yetyala ngesiNgesi nesiTshayina ukuze ubuyisele kwilizwe lakho.
Q.
Ngaba umntu uya kundinceda ukuya kwisikhululo seenqwelomoya xa ndibuyela ekhaya emva konyango?

A.
Ewe, abasebenzi bethu beZiko laMazwe ngaMazwe baya kuyigcina imoto kwaye bakuncede ubeke umthwalo wakho emotweni kwaye bakuse kwisikhululo seenqwelomoya.