Ukusasaza i-B-cell lymphoma enkulu (DLBCL) -04
UMnu. Li, oneminyaka engama-64 ubudala (igama elingaziwa), wafunyaniswa ukuba une-B-cell lymphoma enkulu (i-DLBCL) kwiminyaka emine edlulileyo, eyaqhubela phambili ekubandakanyekeni kwexesha elide le-spleen, iimbambo, imiphunga kunye ne-pleura, echazwe njengesigaba IV. . Ukulandela i-immunochemotherapy yomgca wokuqala, imeko yakhe yahlala ixolile ngaphezu kweminyaka emithathu. Nangona kunjalo, ngoMatshi wonyaka ophelileyo, isifo sakhe saphinda sabuyela, sibandakanya i-lymph nodes ezininzi ze-retroperitoneal. Ngaphandle kwechemotherapy yodidi lwesibini, wafumana uxolelo oluyinxenye kwaye wohla ngokukhawuleza, efuna unyango olusebenzayo ngakumbi ukulawula ukuqhubela phambili.
Ejongene nalo mngeni unzima, iqela leengcali kwiSibhedlele saseLu Daopei liye laphonononga ngokubanzi imeko kaMnu. Unyango lweeseli ze-CAR-T, njengeyona ndlela yakutsha nje ye-tumor immunotherapy, ibonelela ngeengenelo ezibalulekileyo njengokujolisa okuqinileyo kunye nokunyamezela ukusebenza kakuhle kwizigulane ezine-lymphoma ephindaphindayo kunye ne-refractory.
NgoJanuwari 2023, uMnu. Li wafumana unyango lweseli ye-CAR-T kwiSebe le-Lymphoma. Ngaphambi kokuba unyango, wafumana i-biopsy ye-lymph nodes ye-inguinal echanekileyo, eyaqinisekisa ukuba i-CD19 kunye ne-CD20 positivity, ibonelela ngeethagethi ezicacileyo ze-CAR-T yonyango lweseli. Phantsi kwesikhokelo sikaNjingalwazi uLi, iqela lezonyango lenze isicwangciso sonyango lomntu.
NgoJulayi 25, 2023, uMnu. Li wagqiba inkqubo yokufakwa kwe-CD19/20 CAR-T cells, eqhube kakuhle phantsi kweliso elibukhali leqela lezonyango. Ngaphandle kokufumana i-cytokine release syndrome, i-cytopenia, kunye nomngcipheko wokosuleleka emva kokufakwa, ukhathalelo oluqinileyo oluxhasayo lulawule ngempumelelo ukusabela okubi ngexesha lonyango.
Kwiinyanga ezintandathu emva kokuphunyezwa kwe-CAR-T yonyango lweeseli, uMnu Li akazange abonise izilonda ezisebenzayo kuwo wonke umzimba wakhe, ufezekise impendulo epheleleyo ye-metabolic (CMR), eyazisa ithemba elitsha kwimpilo yakhe. Iqela lezonyango liye laphinda longeza izilonda ze-retroperitoneal ezishiyekileyo nge-radiotherapy ukuqinisekisa ukuhlehla okupheleleyo kwesifo kunye nokuzinza kwexesha elide.
Ngale CAR-T cell immunotherapy, uMnu. Li akaphumelelanga nje ukuphuculwa okubalulekileyo kwimeko yakhe kodwa waphinda wafumana ukuzithemba kunye namandla ebomini. Icala lakhe linika ithemba elitsha kunye nesikhokelo kwizigulane ze-lymphoma kwaye libonisa amandla kunye nokusebenza kwe-CAR-T yonyango lwe-cell ekunyangeni i-lymphoma ye-refractory.
Unyango lweeseli ze-CAR-T, njengonyango olutsha lomhlaza, luguqula iindlela zobomi bezigulane ezine-lymphoma ye-refractory. Ngaphantsi kokunyamekela ngokucokisekileyo kweqela leengcali kwiSebe le-Lymphoma, izigulane ezininzi ezifana noMnu. Ukujonga phambili, ukuqhubela phambili kunye nokusetyenziswa konyango lweseli ye-CAR-T kuthembisa amathemba abanzi kunye namathuba kunyango lomhlaza.
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