Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II
Sivuyisana nawe! Isigulana esisuka eNorway, uBjørn Simensen, oneminyaka emibini yoxolelo oluzingileyo.
Indoda eneminyaka engama-67 ubudala u-Bjørn Simensen unikezele esibhedlele ngoSeptemba ka-2017 ngezikhalazo zokukhohlela kunye neentlungu zesifuba. Ngexesha lokusebenza kwakhe, wafunyanwa ene-myeloma eninzi (IgG lambda) ISS-II. Isigulane safumana imijikelezo ye-4 ye-bortezomib, i-lenalidomide kunye ne-dexamethasone chemotherapy. Kwimijikelo yesi-4 iprotheni yakhe ye-M yayingaphantsi kwe-1g/l. Isigulane ke saphuma ukugcinwa kwe-lenalidomide (iiveki ze-10mg qdx3 ngenyanga m) ukuba waqhubeka kwiminyaka eyi-2 elandelayo. Wahlala engenasifo de kwafika ihlobo lika-2021 xa ngexesha lovavanyo loxolelo wafunyaniswa ukuba unyuse i-M protein (5g/l). U-Lenalidomide wayeka kwaye waqaliswa kwi-carfilzomib kunye ne-daratumumab chemotherapy ukususela ngo-Oktobha ukuya kuDisemba 2021. Nangona kunjalo, i-chemotherapy yayingasebenzi kwaye i-post-chemo BM MRD yayilungile.
UMnu Bjørn Simensen wabonwa okokuqala kwiSibhedlele saseLu Daopei nge-14 kaFebruwari 2022. I-BM MRD yakhe ibonise i-0.25 yeepesenti ezingaqhelekanga zeeseli ze-plasma. I-IEF ibonise i-IgG kunye ne-M protein yayiyi-3 g/l. I-PET-CT Scan ibonise ukunyuka kwamatyhalarha ingakumbi elo lifanelekileyo elathi landiswa xa kuvavanywa. Kwenziwa i-testicular biopsy ebonisa iiseli ezinobungozi zeplasma. Isigulane sikhethwe unyango lweseli ye-CART. I-preconditioning yenziwa nge-fludarabine kunye ne-cyclophosphamide kwiintsuku ze-3. Iiseli ze-CAR-T zafakwa ngosuku lwe-0 (4/3/2222). Umthamo onikiweyo wawuyi-0.5X10^6 /kg. Emva kokutofa, isigulana saba ne-neutropenia fever eyayilawulwa nge-iv antibiotics. Ukudumba kwetyhalarha lasekunene kuye kwehliswa ngokuthe chu ukuya kubukhulu obuqhelekileyo. Ngomhla we-28 uviwo lwe-BM lwalungalunganga kwiiseli ze-plasma. Isigulana sakhutshwa eLu Daopei ngokulandelelwa rhoqo kwiziko le-hematology kwisixeko sakhe.
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