I-Acute Lymphoblastic Leukemia(T-ALL)-10

Inkwenkwe eneminyaka eli-13 ubudala egama linguYangyang yasePanzhihua, kwiPhondo laseSichuan, yafumana iCAR-T elandelwa kuqhaqho lokufakela utyando.

UYangyang thaca ekuqaleni "nemikrwelo esasazekileyo emzimbeni wonke ehamba nokudinwa" ngo-Epreli 12, 2021. Wafunyaniswa ukuba une-acute lymphoblastic leukemia (T-cell subtype) kunye ne-intracranial hemorrhage kunye nosulelo lwemiphunga oluqinisekiswa luvavanyo lomongo we-MICM kwisibhedlele esikhulu Chongqing. Wenza imijikelo ye-3 ye-chemotherapy kwesinye isibhedlele, kodwa umongo wethambo awuzange uphendule. Ekuqaleni kukaJuni, waba buthathaka kwimilenze yomibini engaphantsi kwaye wayengakwazi ukuhamba.

NgoJulayi 1, 2021, uYangyang wamkelwa kwiWadi yethu ye-Hematology kwiWadi yesi-2. Wabhalisa kulingo lwezonyango lwe-CD7 CAR-T ngomhla we-8 kaJulayi kwaye wafumana i-CD7 CAR-T cell ye-autologous nge-26 kaJulayi kunyango lomzimba. Kwiintsuku ezilishumi elinesithandathu emva kokufakwa, i-bone marrow morphology yabonisa uxolelo, kwaye i-cytometry yokuhamba ibonise i-0.07% ekrokrelayo enobungozi obungavuthiweyo be-T lymphoblasts. Emva konyango lomzimba, waphinda wakwazi ukuhamba ngokuzimela. Ngomhla wama-31 emva kokufakwa, umongo wakhe wafumana uxolelo olupheleleyo.

Okwangoku, i-Yangyang idluliselwe kwi-Ward 6 yeSebe le-Bone Marrow Transplantation yonyango olongezelelweyo. UGqr. Hai ovela kwiWadi yesi-6 uthe uYangyang ube nentsebenziswano kunye nethemba kulo lonke unyango lwakhe. Wenziwa i-allogeneic hematopoietic stem cell transplantation (esuka kuyise) ngoSeptemba 28. Iimeko ezidalwe ngoogxa bakhe beSebe le-Hematology ukwenzela uqhaqho-fakelo lotyando lwakhe zaxatyiswa kakhulu.

Ezi zigulana, ngaphambi kokubhaliswa kwi-CD7 CAR-T yolingo lwezonyango, zibonakaliswe iimpawu ezahlukeneyo ezifana nokuphindaphinda emva kokutshintshwa, i-T / myeloid intetho ephindwe kabini, i-refractory/resistant acute T-cell leukemia, i-central nervous system leukemia, i-intracranial hemorrhage, kunye usulelo lwemiphunga. Emva kovavanyo kunye nonyango ngonyango lwe-CD7 CAR-T, bonke bazuze ukuxolelwa okupheleleyo, ukuhlangabezana neziphumo ezilindelekileyo.

Isibhedlele saseLudaopei siye sahlola ngenkuthalo kwinkalo yonyango lwe-CAR-T kwaye saqokelela amava atyebileyo ekulawuleni iCRS. Kuninzi lwabathathi-nxaxheba, esona siphumo sibi kakhulu yayiyifiva ephezulu. "Ndinokufezekisa ukuxolelwa okupheleleyo, ngoko ke umkhuhlane awukho nto! Ndifuna abantu abaninzi bazi ukuba uLudaopei unokwenza i-CAR-T!" Wathi uYangyang esuka eFujian ekuphumeni kwakhe.