I-Acute Lymphoblastic Leukemia(T-ALL)-07
Intombazana yaseMiao ifumana uxolelo olupheleleyo emva konyango lwe-CAR-T emva kokubuyela kwimeko yasemva kokutshintshwa.
UAmei, umfundi onesidanga osuka eHunan wesizwe saseMiao, wayepapashe amaphepha amabini eSCI. Nge-2 ka-Epreli, 2020, wangeniswa kwisibhedlele sephondo ngenxa yomkhuhlane oqhelekileyo. Ukuxilongwa komongo kwafumanisa ukuba une-acute lymphoblastic leukemia (T-ALL). Emva kweekhosi ezininzi zechemotherapy kwisibhedlele sangaphandle, umongo wakhe wahlala uxolile. Nge-2 kaNovemba ka-2020, uye wenziwa uqhaqho-fakelo lwe-allogeneic hematopoietic stem cell kwisibhedlele sethu (ubhuti ukuya kudade, umdlalo we-HLA 7/10). Emva kokutshintshwa, iiseli zifakwe ngempumelelo, kwaye iimviwo ezilandelwayo zomongo wamathambo zibonise ukuxolelwa okuqhubekayo.
Ngomhla we-16 kuJuni, ngo-2021 (iinyanga ezisi-7 emva kofakelo), uvavanyo lwesiqhelo lwatyhila ukuphinda ubuyele kwi-leukemia yakhe. Unyango olwalandelayo lwechemotherapy lwasilela ekusilawuleni eso sifo, yaye waba nenyumoniya nosulelo lwentsholongwane yeherpes, enezilonda ezibuhlungu ezisemlonyeni zenza kube nzima ukuginya. Uye wamkelwa kwiwadi yesibini yesebe le-hematology kwaye wabhaliswa kulingo lwezonyango lwe-CD7 CAR-T.
Iqela lezonyango likaMlawuli uYang Junfang libonelele ngonyango olusebenzayo lokuchasa usulelo, ukuthomalalisa iintlungu, kunye negazi elininzi kunye notofelo-gazi lweplatelet. Ngenxa yomthwalo ophakamileyo wethumba (i-80% yokuqhuma kumongo wethambo kunye ne-97% yokuqhuma kwigazi le-peripheral), akuzange kwenzeke ukuqokelela iiseli zakhe. I-lymphocytes yegazi ye-peripheral evela kumxhasi (umntakwabo) yaqokelelwa kwaye yathunyelwa kwinkampani ye-biotech yenkcubeko ye-CAR-T yeseli.
Ngomhla we-10 ka-Agasti, ngo-2021, iiseli ze-CD7 CAR-T eziphuma kumxhasi zaphinda zafakwa. Emva kokubuyiselwa kwakhona, iiseli ze-CAR-T zanda ukuya kwi-54.64% kwigazi le-peripheral, kunye nomkhuhlane kuphela kwaye akukho nto ebalulekileyo ye-cytokine release syndrome (CRS) okanye isifo se-graft-versus-host (GVHD). Uvavanyo lwe-Bone marrow ngosuku lwe-16 emva kokubuyiselwa kwakhona lubonise ukuxolelwa okupheleleyo, kunye ne-54.13% yeeseli ze-CAR-T kumongo wethambo. Ngomhla wama-36, umongo wamathambo waqhubeka ubonisa uxolelo oluqhubekayo. Sithetha nje, imeko yakhe yengqondo, ukulala, kunye nomdla wokutya zilungile, kwaye uchacha kakuhle.
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