Leano la Novel Promoter le Ntlafatsa Polokeho le Matla a Phekolo ea CAR-T ho Acute B Cell Leukemia.
Beijing, China – Phupu 23, 2024- Ka nts'etsopele e kholo, Sepetlele sa Lu Daopei, se sebelisana le Hebei Senlang Biotechnology, se senotse liphello tse tšepisang ho tsoa thutong ea bona ea morao-rao mabapi le phekolo ea lisele tsa chimeric antigen receptor T (CAR-T). Phuputso ena, e shebaneng le katleho le polokeho ea lisele tsa CAR-T tse entsoeng ka batšehetsi ba fapaneng, e tšoaea tsoelo-pele e kholo kalafong ea leukemia e matla ea B cell (B-ALL).
Thuto, e nang le sehlooho se reng "Tšebeliso ea Batšehetsi e Laolang Tekano ea Bokaholimo ba Limolek'hule tsa CAR E ka Fetola Kinetics ea Lisele tsa CAR-T Ka Vivo," e hlahloba kamoo khetho ea motšehetsi e ka susumetsang ts'ebetso ea lisele tsa CAR-T. Bafuputsi Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, le Jianqiang Li ba tsoang Hebei Senlang Biotechnology le Sepetlele sa Lu Daopei ba etelletse pele lipatlisiso tsena.
Liphuputso tsa bona li bonts'a hore ho sebelisa MND (myeloproliferative sarcoma virus MPSV enhancer, taolo e mpe ea NCR deletion, d1587rev primer binding site replacement) ka liseleng tsa CAR-T ho lebisa ho theolelo ea bokaholimo ba limolek'hule tsa CAR, tseo le tsona li fokotsang tlhahiso ea cytokine. Sena ke sa bohlokoa hobane se thusa ho fokotsa litla-morao tse matla tse atisang ho amahanngoa le phekolo ea CAR-T, e kang cytokine release syndrome (CRS) le CAR-T cell-related encephalopathy syndrome (CRES).
Teko ea tleliniki, e ngolisitsoeng tlas'a sekhetho sa ClinicalTrials.gov NCT03840317, e kenyelelitse bakuli ba 14 ba arotsoeng ka lihlopha tse peli: e mong a fumana lisele tsa CAR-T tse tsamaisoang ke MND 'me e mong a fumana lisele tsa CAR-T tse tsamaisoang ke EF1A. Hoa makatsa hore ebe bakuli bohle ba ileng ba phekoloa ka lisele tsa CAR-T tse tsamaisoang ke MND ba ile ba fumana phokolo e feletseng, 'me boholo ba bona ba bontša boemo bo fokolang ba ho se be le mafu ka mor'a khoeli ea pele. Phuputso e boetse e tlalehile boemo bo fokolang ba CRS le CRES e matla ho bakuli ba tšoaroang ka lisele tsa CAR-T tse tsamaisoang ke MND ha li bapisoa le ba tšoaroang ka lisele tse tsamaisoang ke EF1A.
Dr. Peihua Lu oa Sepetlele sa Lu Daopei o bontšitse tšepo mabapi le bokhoni ba mokhoa ona o mocha, a re, "Tšebelisano ea rona le Hebei Senlang Biotechnology e fane ka lintlha tsa bohlokoa mabapi le ho ntlafatsa phekolo ea lisele tsa CAR-T. Ka ho fetola mothetsi, re ka ntlafatsa boemo ba tšireletso ea kalafo ha e ntse e boloka matla a eona a ts'ebetso Ena ke mohato oa bohlokoa oa ho etsa hore kalafo ea CAR-T e fihlellehe le ho mamelleha ho bakuli.
Boithuto bona bo tšehelitsoe ke lithuso tse tsoang ho Natural Science Foundation ea Profinse ea Hebei le Lefapha la Saense le Thekenoloji ea Profinse ea Hebei. E totobatsa bohlokoa ba khetho ea batšehetsi ntlafatsong ea kalafo ea lisele tsa CAR-T mme e bula mekhoa e mecha bakeng sa kalafo e sireletsehileng le e sebetsang haholoanyane ea mofets'e.