Tšebeliso ea nako e telele ea CD19 CAR T-Cell Therapy ho Phekolo ea Relapsed/Refractory Acute Lymphoblastic Leukemia.
Khatelo-peleng e kholo lefapheng la hematology, phuputso ea morao tjena e bontšitse katleho ea nako e telele ea CD19 chimeric antigen receptor (CAR) T-cell therapy ho bakuli ba nang le lefu la ho khutlela morao / refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem. transplantation ea sele (allo-HSCT). Phuputso, e latelang bakuli ka nako e telele, e fana ka tlhahlobo e pharaletseng ea liphello, e fana ka lintlha tsa bohlokoa mabapi le ho tšoarella le polokeho ea phekolo ena e ncha.
Boithuto bona bo ile ba latella bakuli ba ileng ba fumana kalafo ea CD19 CAR T-cell ka mor'a ho khutlela mokhoeng oa ALL ka mor'a allo-HSCT. Liphello li fana ka tšepo, li bontša hore karolo e kholo ea bakuli e finyelletse tšoarelo e feletseng, ka likarabo tse tsitsitseng tse hlokometsoeng ho theosa le lilemo. Patlisiso ena ha e totobatse feela matla a kalafo a CAR T-cell therapy empa hape e tšoaea mohato oa bohlokoa kalafong ea malignancy ea mali, haholo-holo ho ba nang le likhetho tse fokolang tsa kalafo.
Ho feta moo, boithuto bo shebana le boemo ba polokeho ea kalafo, e tlaleha litla-morao tse laolehang, tse neng li lumellana le liphuputso tsa pejana. Sena se matlafatsa ts'epo e ntseng e hola ea kalafo ea CAR T-cell e le kalafo e sebetsang le e sebetsang bakeng sa TSOHLE e khutletseng hape, haholo maemong a kamora ho fetisoa.
Ha lefapha la immunotherapy le ntse le tsoela pele ho fetoha, thuto ena e sebetsa e le lebone la tšepo ho bakuli le bafani ba tlhokomelo ea bophelo ka ho tšoanang, e tšepisa bokamoso moo bakuli ba bangata ba ka fihlelang tšoarelo ea nako e telele. Liphuputso ha li kenye letsoho feela bopaking bo ntseng bo hola bo tšehetsang kalafo ea CAR T-cell empa hape li bula tsela bakeng sa lipatlisiso tse ling ho ntlafatsa le ho holisa ts'ebeliso ea eona maemong a bongaka.
Ka katleho ena, sechaba sa bongaka se atamela haufi le ho fetola sebaka sa phekolo bakeng sa mafu a hematological, ho fana ka tšepo e ncha ho bakuli ba loanang le maemo ana a thata.