Mekhoa e Mecha ea Phekolo ea Lisele ea CAR-T e Fetola Phekolo ea Mafu a B Cell
Phuputsong ea morao-rao e hatisitsoeng ho Journal of the National Cancer Center, litsebi tsa Sepetlele sa Lu Daopei, tse etelletsoeng ke Dr. Peihua Lu, hammoho le basebetsi-'moho le The University of Texas MD Anderson Cancer Center, li fane ka leseli mabapi le tsoelo-pele ea morao-rao ea CAR-T. kalafo ea lisele bakeng sa kalafo ea B-cell malignancies. Tlhahlobo ena e pharaletseng e tšohla mekhoa e mengata e mecha, ho kenyelletsa le phetoho ea moralo oa lisele tsa CAR-T le ho kopanngoa ha mekhoa ea phekolo ea lisele, ho ntlafatsa katleho le polokeho ea phekolo ea mafu a kang non-Hodgkin's lymphoma (NHL) le acute lymphoblastic leukemia (ALL). ).
Boloetse ba B-cell bo baka mathata a maholo ka lebaka la tšekamelo ea bona ea ho khutlela morao le ho ba le khanyetso ea mekhoa e tloaelehileng ea phekolo. Kenyelletso ea lisele tsa T tsa chimeric antigen receptor (CAR) e fetotse boemo ba kalafo, e fana ka tšepo e ncha ho bakuli ba tobaneng le mofets'e ona o mabifi. Boithuto bona bo totobatsa hore na lisele tsa CAR T li ka etsoa joang ka meloko e mengata ea moralo, ho kenyelletsa likarolo tse tsoetseng pele joalo ka li-receptor tsa bispecific le libaka tsa theko e phahameng, ho lebisa lisele tsa tumor ka katleho le ho fokotsa monyetla oa ho khutlela mokhoeng.
Sepetlele sa Lu Daopei se 'nile sa etella pele lipatlisiso tsa lisele tsa CAR-T le ts'ebeliso ea meriana ea bongaka, e bontšang katleho e tsotehang ea ho fana ka phomolo ea nako e telele. Ho kenya letsoho ha sepetlele mosebetsing ona oa bopula-maliboho ho totobatsa boitlamo ba bona ba ho ntšetsa pele phekolo ea mofetše le ho fana ka tlhokomelo ea boemo bo holimo. Tlhahlobo e boetse e hlahloba bokhoni ba ho kopanya mekhoa ea phekolo ea CAR-T le mekhoa e meng ea phekolo, e kang immunotherapy le mekhoa ea phekolo e lebisitsoeng, ho hlōla mekhoa ea ho hanyetsa le ho ntlafatsa liphello tsa mokuli.
Khatiso ena ke bopaki ba boikitlaetso ba tšebelisano-'moho ea bafuputsi le lingaka tsa machaba ho sututsa meeli ea phekolo ea mofetše. Liphuputso li fana ka leseli la bokamoso ba oncology e nepahetseng, moo liphekolo tsa motho ka mong le tse ncha li ka fetolang bophelo ba bakuli ba nang le lefu la B cell. Linyehelo tsa Sepetlele sa Lu Daopei lebaleng lena ke leseli la tšepo, se tsamaisang nts'etsopele ea kalafo e sireletsehileng le e sebetsang haholoanyane ea mofetše.