Tsoelo-pele e Tsoelang Pele Liseleng tsa 'Molai oa Tlhaho (NK) Ho feta Lilemo tse 50
Ho tloha ha litlaleho tsa pele tsa li-lymphocyte li bonts'a "polao e sa tobang" ea lisele tsa tumor ka 1973, kutloisiso le bohlokoa ba lisele tsa Natural Killer (NK) li fetohile haholo. Ka 1975, Rolf Kiessling le basebetsi-'moho le eena Setsing sa Karolinska ba ile ba qapa lentsoe "Natural Killer" lisele, ba totobatsa bokhoni ba bona bo ikhethang ba ho hlasela lisele tsa hlahala ntle le ts'usumetso pele.
Lilemong tse mashome a mahlano tse tlang, lilaboratori tse ngata lefats'eng ka bophara li ithutile ka ho pharaletseng NK cell in vitro ho hlakisa karolo ea bona ts'ireletsong ea moeti khahlano le lihlahala le likokoana-hloko tsa likokoana-hloko, hammoho le mesebetsi ea bona ea taolo ka har'a sesole sa 'mele.
NK Lisele: The Pioneering Innate Lymphocyte
Lisele tsa NK, litho tsa pele tse khetholloang tsa lelapa la innate lymphocyte, li sireletsa khahlanong le lihlahala le likokoana-hloko ka ts'ebetso e tobileng ea cytotoxic le secretion ea cytokines le chemokines. Pele ho thoe ke "lisele tse se nang letho" ka lebaka la ho ba sieo ha matšoao a khethollang, tsoelo-pele ea tatellano ea sele e le 'ngoe ea RNA, cytometry ea phallo, le spectrometry ea boima li lumelletse ho aroloa ka botlalo ha NK cell subtypes.
Lilemo tse leshome tsa pele (1973-1982): Ho sibolla Cytotoxicity e sa Tobang
Ho elella bofelong ba lilemo tsa bo-1960 le mathoasong a lilemo tsa bo-1970 ho ile ha etsoa litlhahlobo tse bonolo tsa in vitro ho lekanya cytotoxicity ea lisele. Ka 1974, Herberman le basebetsi-'moho ba ile ba bontša hore li-lymphocyte tsa mali tse tsoang ho batho ba phelang hantle li ka bolaea lisele tse sa tšoaneng tsa lymphoma ea batho. Kiessling, Klein, le Wigzell ba ile ba boela ba hlalosa lysis e itlelang feela ea lisele tsa hlahala ka li-lymphocyte tse tsoang litoeba tse se nang hlahala, ba reha ketsahalo ena "polao ea tlhaho."
Lilemo tse Leshome tsa Bobeli (1983-1992): Phenotypic Characterization le Viral Defense
Lilemong tsa bo-1980, tsepamiso e ile ea fetohela ho sebopeho sa phenotypic sa lisele tsa NK, se lebisang ho khethoeng ha li-subpopulations tse nang le mesebetsi e ikhethileng. Ka 1983, bo-rasaense ba ne ba se ba khethile likaroloana tse fapaneng tse sebetsang tsa lisele tsa NK tsa motho. Liphuputso tse ling li ile tsa totobatsa karolo ea bohlokoa ea lisele tsa NK ho sireletsa khahlanong le herpesviruses, e bontšitsoeng ke mokuli ea nang le tšoaetso e matla ea herpesvirus ka lebaka la khaello ea liphatsa tsa lefutso tsa NK cell.
Leshome la Boraro (1993-2002): Ho Utloisisa Li-Receptors le Ligands
Khatelo-pele e kholo lilemong tsa bo-1990 le mathoasong a lilemo tsa bo-2000 e lebisitse ho khethoeng le ho kopanya li-receptor tsa NK le li-ligands tsa tsona. Lintho tse sibolotsoeng tse kang NKG2D receptor le li-ligands tse bakoang ke khatello ea kelello li thehile motheo oa ho utloisisa mekhoa ea ho lemoha lisele tsa NK "altered-self".
Leshome la Bone (2003-2012): NK Cell Memory le Licensing
Ho fapana le maikutlo a tloaelehileng, liphuputso tsa lilemong tsa bo-2000 li bontšitse hore NK lisele li ka hlahisa likarabo tse kang mohopolo. Bafuputsi ba bontšitse hore lisele tsa NK li ka khona ho buisana le likarabo tse khethehileng tsa antigen le ho hlahisa mofuta oa "memori" e tšoanang le lisele tsa 'mele tsa ho itšireletsa mafung. Ho feta moo, mohopolo oa "license" tsa NK cell o ile oa hlaha, o hlalosa kamoo ho sebelisana le limolek'hule tsa MHC ho ka ntlafatsang karabelo ea lisele tsa NK.
Lilemo tse Leshome la Bohlano (2013-Hona joale): Likopo tsa Meriana ea Meriana le Mefuta-futa
Lilemong tse leshome tse fetileng, tsoelo-pele ea theknoloji e tsamaisitse lipatlisiso tsa lisele tsa NK. Mass cytometry le tatellano ea sele e le 'ngoe ea RNA e senotse mefuta e mengata ea phenotypic har'a lisele tsa NK. Ka kakaretso, lisele tsa NK li bonts'itse ts'episo ea ho phekola mafu a mali, joalo ka ha ho bonts'itsoe ke ts'ebeliso e atlehileng ea lisele tsa CD19 CAR-NK ho bakuli ba lymphoma ka 2020.
Litebello tsa Bokamoso: Lipotso tse sa arajoang le Mecha e Mecha
Ha lipatlisiso li ntse li tsoela pele, ho ntse ho e-na le lipotso tse ’maloa tse thahasellisang. Lisele tsa NK li fumana mohopolo o ikhethileng oa antigen joang? Na lisele tsa NK li ka sebelisoa ho laola mafu a autoimmune? Re ka hlola mathata a bakoang ke tumor microenvironment ho kenya lisele tsa NK ka katleho joang? Lilemo tse mashome a mahlano tse tlang li tšepisa lintho tse thabisang le tse neng li sa lebelloa ho NK cell biology, tse fanang ka mekhoa e mecha ea phekolo bakeng sa mofetše le mafu a tšoaetsanoang.