Bioocus e Tsoela Pele ho Phekolo ea Acute Lymphoblastic Leukemia
Ketsahalo ea bohlokoa tšimong ea phekolo ea CAR-T, e bontšitsoeng ke khatiso ea morao-rao ea thuto ea motheo e etelletsoeng ke Dr. Chunrong Tong Sepetlele sa Lu Daopei. Boithuto bona, bo bitsoang "Phihlelo le Liphephetso tsa CD19 CAR-T Cell Therapy in Pediatric Acute Lymphoblastic Leukemia," e fana ka tlhahlobo e felletseng ea katleho le polokeho ea moloko oa bobeli oa CD19 CAR-T cell therapy ho alafong acute lymphoblastic leukemia. (TSOHLE).
Patlisiso ena e totobatsa bokhoni ba boqapi ba sehlahisoa sa Bioocus's CAR-T ho sebetsana le e 'ngoe ea maemo a thata ka ho fetisisa a amanang le mali baneng. Boithuto bona bo hlakisa liphetho tsa kliniki tse hlokometsoeng ho bakuli ba ileng ba fumana kalafo ena, ho senola litekanyetso tse tšepisang tsa tšoarelo. Leha ho le joalo, e boetse e supa liphephetso tse mahlonoko, haholo-holo taolo ea lefu le matla la tokollo ea cytokine (CRS) le neurotoxicity, tse lulang e le libaka tsa bohlokoa tsa ho tsepamisa maikutlo ho ntlafatsa polokeho ea mokuli.
Bioocus's CAR-T therapy, e hlahisitsoeng thutong ena, e sebelisa moralo oa moloko oa bobeli o ntlafatsang ts'ebetso ea T-cell khahlano le lisele tsa mofetše tse hlahisang antigen ea CD19. Mokhoa ona o bohlokoa ho hlola mekhoa ea bohanyetsi e atisang ho kopana le maemo a TSOHLE a bana a khutlelang morao kapa a hananang. Liphetho tse hlahisitsoeng khatisong ena ha li totobatse feela matla a kalafo a sehlahisoa sa Bioocus's CAR-T empa hape li totobatsa bohlokoa ba boqapi bo tsoelang pele le lipatlisiso tsa bongaka ho ntlafatsa liphekolo tsena ho ea pele.
Patlisiso ea Dr. Tong e kenya letsoho litsebo tsa bohlokoa mabapi le ts'ebeliso ea liphekolo tsa CAR-T mme e tsamaellana le morero oa Bioocus oa ho ntšetsa pele kalafo ea mofets'e ka litharollo tsa morao-rao tsa biotechnological. Joaloka moetapele oa lefats'e oa nts'etsopele ea CAR-T, Bioocus o ntse a ikemiselitse ho sutumelletsa meeli ea se ka khonehang kalafong ea mofetše, ka sepheo sa ho qetela sa ho ntlafatsa litholoana tsa mokuli le boleng ba bophelo.
Ha Bioocus e ntse e tsoela pele ho sebelisana le litsi tsa bongaka tse etelletseng pele joalo ka Sepetlele sa Lu Daopei, re ntse re ikemiseditse ho sebetsana le diphephetso tse hlwauweng phuputsong ena le ho hlwekisa dihlahiswa tsa rona tsa CAR-T ho matlafatsa polokeho le katleho ya tsona. Boitlamo ba rona ba bokhabane le boqapi bo netefatsa hore re boemong bo botle ba ho etella pele bokamoso ba kalafo ea mofets'e.