Tlhaloso e Pharalletseng ea Kalafo ea Groundbreaking Leukemia
Lipontšo tsa CAR-T
●B-cell acute lymphoblastic leukemia
●Myeloma e mengata
●Chronic lymphocytic leukemia
●Non-Hodgkin lymphoma
●E hasanya B-cell lymphoma e kholo
●SLE (System Lupus Erythematosus)
●Myasthenia gravis
●Mafu a mang a autoimmune
Ts'ebetso e ntle ea kliniki ea CAR-T
Matšoao a CD19+20CAR-T:Bakuli ba nang le B-cell non Hodgkin's lymphoma
Sekhahla sa CR sa khoeli e le 'ngoe | Sekhahla sa PR sa khoeli e le 'ngoe | Khoeli e le 'ngoe KAPA reiti | CRS≥3 | CRES≥3 |
71.95% (59/82) | 25.6 (21/82) | 97.55 (80/82) | 12.19% (10/82) | 0 |
Matšoao a CD19+22CAR-T:Kalafo ea bakuli ba CD19 ba khutletseng morao le ba refractory acute B-lymphocytic leukemia
Sekhahla sa CR sa khoeli e le 'ngoe | Sekhahla sa PR sa khoeli e le 'ngoe | Khoeli e le 'ngoe KAPA reiti | CRS≥3 | CRES≥3 |
92.1% (35/38) | 7.9% (3/38) | 100% (38/38) | 15.79% (6/38) | 0 |
Matšoao a BCMACAR-T:Kalafo ea ho khutlela morao le ho hanyetsa multiple myeloma
Sekhahla sa CR sa khoeli e le 'ngoe | Sekhahla sa PR sa khoeli e le 'ngoe | Khoeli e le 'ngoe KAPA reiti | CRS≥3 | CRES≥3 |
72.41% (21/29) | 27.59% (8/29) | 100% (29/29) | 6.9% (2/29) | 0 |
Melemo ea Rōna
● Kalafo ea Motho: Kalafo e 'ngoe le e' ngoe ea CAR-T e etselitsoe mokuli, ho netefatsa liphello tse lebisitsoeng haholo le tse sebetsang tsa phekolo.
● Likhetho tse fapaneng tsa ho Lebela: Ka mefuta e mengata ea li-antigen tse lebisitsoeng, ho kenyeletsoa CD7, CD19, CD20, CD22, le BCMA, lihlahisoa tsa rona tsa CAR-T li fana ka mefuta-futa e ke keng ea lekanngoa ho phekola mafu a sa tšoaneng a hematological le mafu a autoimmune.
● Pakiloeng Clinical Katleho: Liphekolo tsa rona tsa CAR-T li bonts'itse katleho e ikhethang ho pholletsa le linyeoe tse ngata tsa bongaka, ka litekanyetso tse tsotehang tsa phokolo le litlaleho tsa polokeho, tse matlafatsang boemo ba rona ba ho ba moetapele oa immunotherapy.
● Litsenyehelo tse Phahameng ka ho Fetisisa: Re fana ka monyetla oa tlholisano ka liphekolo tsa boleng bo holimo ka litheko tse fumanehang habonolo ha li bapisoa le lihlahisoa tse ling tsa CAR-T 'marakeng.
● Theknoloji e tsoetseng pele: Ho sebelisa tsoelo-pele ea morao-rao ea boenjiniere ba liphatsa tsa lefutso, liphekolo tsa rona tsa CAR-T li kenyelletsa bokamoso ba mofetše le kalafo ea lefu la autoimmune.
● Setsebi sa Tšehetso ea Bongaka: Sehlopha sa rona sa lingaka le bafuputsi ba nang le phihlelo se fana ka tlhokomelo e feletseng ho tloha lipuisanong tsa pele ka tsamaiso ea phekolo le ho latela.
Lisele tsa CAR-T li se li tsebahala haholo ka katleho ea tsona ho bakuli ba sa kang ba arabela kalafo ea setso joalo ka chemotherapy kapa transplantation ea masapo. Setsi sa lefats'e sa bongaka se amohela monyetla o moholo oa phekolo ea CAR-T ho fetola liphello tsa bakuli.
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