Wararka

Daraasad dhowaan lagu sameeyay Isgaadhsiinta Dabeecadda ayaa daaha ka qaadaysa fikradaha muhiimka ah ee waddooyinka calaamadaynta ee wax ka beddelaya waxtarka burburinta borotiinka ee la beegsaday iyadoo la adeegsanayo PROTACs. Daahfurkaani wuxuu u gogol xaarayaa daawaynta waxtarka leh ee kansarka iyo cudurada kale.

Xaqiijinta waayo-aragnimada daawaynta ee badbaadada iyo raaxada leh ee bukaanka leukemia waxay ku lug leedahay daryeel maalinle ah oo taxadar leh, oo ay ku jiraan nadaafadda deegaanka, nadaafadda shakhsi ahaaneed, nafaqada, iyo jimicsiga habboon. Hagahan waxa uu bixiyaa tabo lagama maarmaan u ah daryeel maalmeed wax ku ool ah si loo taageero soo kabashada.

Daraasad dhowaan la sameeyay ayaa iftiimisay waxtarka iyo badbaadada daawaynta unugyada NS7CAR-T ee daawaynta soo noqoshada ama dib-u-celinta T-cell lymphoblastic leukemia (R/R T-ALL) iyo T-cell lymphoblastic lymphoma (R/R T-LBL). Daawayntani waxay rajo cusub siinaysaa bukaanada qaba noocyadan halista ah ee kansarka.

Daraasad dhowaan la sameeyay ayaa iftiimisay natiijooyinka rajo-gelinta ah ee CD7-bartilmaameedka daawaynta unugyada antigen-ka (CAR) T ee lagu daweynayo bukaannada qaba soo noqoshada ama dib-u-celinta T-cell lymphoblastic leukemia (T-ALL) iyo T-cell lymphoblastic lymphoma (T-LBL).

Kulanka Sannadlaha ah ee 66aad ee Bulshada Maraykanka ee Dhiig-baxa (ASH) ayaa la qaban doonaa laga bilaabo Disembar 7-10, 2024, Xarunta Shirarka San Diego, oo soo bandhigaysa cilmi-baaris hor-u-dhac ah iyo horumarinta dhiigga.

Madasha 12-aad ee Sannadlaha ah ee Lu Daopei Hematology ayaa lagu wadaa in uu ka dhaco Agoosto 23-24, 2024, Xarunta Shirarka Caalamiga ah ee Beijing. Nagu soo biir si aad u hesho doodo xeel dheer iyo horumarradii ugu dambeeyay ee xagga dhiigbaxa.

In kasta oo ay jiraan caqabadaha socda ee xagga warshadaynta iyo ganacsi-abuurka, xaddidaadaha daawaynta CAR-T waxa lagu xalliyaa hab cusub oo rajo leh: daawaynta Tumor-Infiltrating Lymphocyte (TIL). Horumarkaani wuxuu ku bishaareynayaa waa cusub oo dagaalka lagula jiro burooyinka adag.

Daawaynta kacaanka ee kansarka waxa kale oo laga yaabaa inay awoodo inay daweyso oo dib u dejiso nidaamka difaaca si ay u bixiso cafis wakhti dheer ah ama suurtogal ah xitaa inay daaweyso cudurada difaaca jirka qaarkood.

Daraasaadka kiliinikada ee wejiga I ee CD7 CAR-T ee R/R AML ee kooxda Daopei Lu ayaa markii ugu horeysay ka soo muuqday ASSH. .

Bulshada Maraykanka ee Hematology (ASH) waa kulanka ugu sarreeya ee cilmi-nafsiga ee goobta dhiigbaxa adduunka oo dhan. Xaqiiqda ah in Isbitaalka Lu Daopei loo doortay inuu noqdo finalka ASH sanado isku xigta waxay si buuxda u muujineysaa guulihiisa waxbarasho ee f...

Shirkii Sannadlaha ahaa ee 65-aad ee Bulshada Maraykanka ee Dhiig-baxa (ASH) ayaa lagu qabtay 9 ilaa 12 Diseembar 2023, San Diego, USA. Iyada oo ah dhacdo tacliineed heer sare ah ee ugu weyn uguna baaxadda weyn ee dhiigbaxa adduunka, waxay soo jiidataa kumanaan khubaro iyo aqoonyahanno ah oo ka kala yimid dhammaan daafaha caalamka