Myasthenia gravis-02

Sheekada Daaweynta Myasthenia Gravis ee Li Ming

Li Ming, oo ah macalin 35 jir ah, ayaa bilaabay in uu la kulmo calaamadaha cudurka myasthenia gravis (MG) saddex sano ka hor. Markii hore, waxa uu ogaaday ptosis (xididka indhaha oo sii dhacaya) iyo hadalka oo ku adag, laakiin astaamuhu waxay si tartiib tartiib ah u sii gudbeen daciifnimada murqaha guud, taasoo ka dhigaysa xitaa dhaqdhaqaaqyada maalinlaha ah ee adag. In kasta oo lagu sameeyay daawayn kala duwan, oo ay ku jiraan steroids iyo immunosuppressants, calaamadihiisa ayaa ahaa kuwo aan la xakameynin.

Horudhac saaxiibkiis ah, Li Ming wuxuu yimid Isbitaalka Lu Daopei si uu uga qaybqaato tijaabada caafimaad ee CAR-T. Koox khubaro ah ayaa sameeyay qiimeyn tafatiran oo ku saabsan astaamihiisa waxayna u diyaariyeen daawaynta CAR-T.

Habka daawaynta:

1. Wajiga diyaarinta: daawaynta ka hor, Li Ming waxa uu maray qiimayn caafimaad oo dhamaystiran. Dhakhaatiirtu waxay go'doomiyeen unugyada T ee jidhkiisa waxayna si hidde ahaan wax uga beddeleen shaybaarka si ay u muujiyaan reseptors-ka antigen-ka (CAR) ee bartilmaameedsanaya antigens gaar ah oo la xidhiidha myasthenia gravis.

2. Balaadhinta Unugyada: Unugyada CAR-T ee wax laga beddelay ayaa lagu balaadhiyey shaybaadhka si loo hubiyo tiro ku filan oo daaweyn ah.

3. Qalabaynta Chemotherapy: Kahor faleebada unugga CAR-T, Li Ming waxa la mariyey dajin kiimiko ah oo toddobaadle ah si loo dhimo tirada lymphocytes ee jirkiisa ku jira, taas oo u abuuraysa jawi ka wanaagsan unugyada CAR-T si ay si hufan ugu shaqeeyaan.

4. Faleebo Unug ee CAR-T: Ka dib markii la dhammeeyey daaweynta kiimoterabiga, Li Ming ayaa isbitaal la dhigay si loo helo faleebo unug CAR-T ah. Nidaamkan waxaa lagu sameeyay kormeer adag si looga hortago waxyeellooyinka iman kara.

Natiijooyinka daawaynta:

1. Jawaab-celinta muddada-gaaban: Toddobaadkii ugu horreeyay ee faleebada ka dib, Li Ming wuxuu la kulmay qandho fudud iyo daal, falcelinno caadi ah oo muddada gaaban ah ee daaweynta unugyada CAR-T. Laba toddobaad ka dib, ptosis-kii iyo dhibtii uu ku hadlay ayaa si weyn u soo roonaaday, xooggiisuna wuxuu bilaabay inuu soo laabto.

2. Horumarka Dhex-dhexaadka ah:Laba bilood ka dib, calaamadaha Li Ming ayaa si muuqata u yareeyey. Waxa uu awooday in uu dib u bilaabo hawlihii waxbaridda ee caadiga ahaa, hufnaantiisa shaqadu waa ay soo hagaagtay, tayada noloshuna waxa ay muujisay horumar la taaban karo.

3. Saamaynta muddada-dheer: Saddex bilood ka dib daawaynta, Li Ming kuma tiirsanayn dawooyin hore. Baaritaanno daba-gal ah ayaa muujiyay in habka difaaca jirkiisu uu wanaagsan yahay, iyada oo aan la arkin waxyeellooyin daran.

Iyada oo loo marayo daaweynta unugyada CAR-T, Li Ming's myasthenia gravis si weyn ayaa loo xakameeyay. "Runtii aad ayaan ugu mahad naqayaa daawaynta CAR-T iyo kooxda caafimaadka ee u heellan dadaalkooda," Li Ming ayaa isagoo ilmeynaya yiri, isagoo gacan qaadaya dhakhtarka markii laga saaray.